ASSOCIATION STUDY OF THE VDR RS731236 AND RS7975232 POLYMORPHYSMSWITH MS IN POPULATION OF KHUZESTAN PROVINCE

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GHAEMI SHADI; SHAFIEI MOHAMMAD; GHALEHDARI HAMID; PORMEHDI BROJENI MEHDI

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Journal: Jundishapur Scientific Medical Journal Year:2017 | Volume:16 | Issue:4 Page(s): 455-465

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Title

ASSOCIATION STUDY OF THE VDR RS731236 AND RS7975232 POLYMORPHYSMSWITH MS IN POPULATION OF KHUZESTAN PROVINCE

Author(s)

GHAEMI SHADI | SHAFIEI MOHAMMAD | GHALEHDARI HAMID | PORMEHDI BROJENI MEHDI | Issue Writer Certificate

Keywords

POLYMORPHYSMSQ1

RS731236Q2

RS7975232Q1

VDRQ1

GENEQ1

MULTIPLE SCLEROSISQ1

Abstract

Background and Objecitve: MULTIPLE SCLEROSIS (MS) is aninflammatory, demyelinating disease of the central nervous system(CNS). MS is determined by interaction between GENEs andenvironment. In the past decade, much attention has been given tovitamin D and its role in MS. Recent data implicate vitamin D inmodulation of the risk as well as clinical course of disease. Sincevitamin D acts through the vitamin D receptor (VDR) the aim ofour study was to determine the association between the VDRrs731236 and RS7975232 polymorphisms and the MS risk inpopulation of Khuzestan province. Subjects and Methods: This study comprised 150 MS cases, plus150 healthy individuals as a control group. For all subjects, level ofvitamin D in serum was measured and association of the VDRrs731236 and RS7975232 polymorphisms and the MS risk wasdetermined using PCR amplification and then RFLP. Data wasconfirmed by direct sequencing. Statistical analyses wereperformed using SPSS version 16. 0. Results: Level of vitamin D in serum of case and control groupswere not differed. The RS731236 polymorphism odds ratios for AAand GG genotypes were 1. 2 (P=0. 46) and 1. 51 (P=0. 33) comparedwith the AG genotype, respectively. The RS7975232 (C/A)polymorphism odds ratios for CA and AA genotypes were 8. 65(P=<0. 001) and 1. 38 (P=<0. 001) compared with the CC genotype, respectively. Conclusion: The RS7975232 polymorphism in VDR GENE did notshow association with MS, but RS7975232 polymorphism showedgood association with this disease.

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APA: Copy

GHAEMI, SHADI, SHAFIEI, MOHAMMAD, GHALEHDARI, HAMID, & PORMEHDI BROJENI, MEHDI. (2017). ASSOCIATION STUDY OF THE VDR RS731236 AND RS7975232 POLYMORPHYSMSWITH MS IN POPULATION OF KHUZESTAN PROVINCE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 16(4 ), 455-465. SID. https://sid.ir/paper/12891/en

Vancouver: Copy

GHAEMI SHADI, SHAFIEI MOHAMMAD, GHALEHDARI HAMID, PORMEHDI BROJENI MEHDI. ASSOCIATION STUDY OF THE VDR RS731236 AND RS7975232 POLYMORPHYSMSWITH MS IN POPULATION OF KHUZESTAN PROVINCE. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2017;16(4 ):455-465. Available from: https://sid.ir/paper/12891/en

IEEE: Copy

SHADI GHAEMI, MOHAMMAD SHAFIEI, HAMID GHALEHDARI, and MEHDI PORMEHDI BROJENI, “ASSOCIATION STUDY OF THE VDR RS731236 AND RS7975232 POLYMORPHYSMSWITH MS IN POPULATION OF KHUZESTAN PROVINCE,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 16, no. 4 , pp. 455–465, 2017, [Online]. Available: https://sid.ir/paper/12891/en

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