The Effect of Short Endurance Training on PGC-1α /FNDC5/BDNF Signalling Pathway In 6-OHDA-Induced Parkinson’ s Rats

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REZAEE ZEINAB; MARANDI SAYED MOHAMMAD; ALAEI HOJJATALLAH; ESFARJANI FAHIMEH

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Journal: JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE) Year:2019 | Volume:15 | Issue:29 Page(s): 15-26

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Title

The Effect of Short Endurance Training on PGC-1α /FNDC5/BDNF Signalling Pathway In 6-OHDA-Induced Parkinson’ s Rats

Author(s)

REZAEE ZEINAB | MARANDI SAYED MOHAMMAD | ALAEI HOJJATALLAH | ESFARJANI FAHIMEH | Issue Writer Certificate

Keywords

ApomorphineQ1

Parkinson ’s diseaseQ2

TrainingQ1

PGC-1αQ1

Abstract

Background&Purpose: Parkinson’ s disease is a neurodegenerative disorder that is characterized by impairment on behavioral, cognitive and biochemical. This study investigated the effect of endurance Training after the 6-OHDA induction, on PGC-1α , FNDC5 and BDNF expression. Methodology: In this study, Parkinson’ s rats were made by 8􀀁 g injection of 6-OHDA into the Medial Forebrain Bundle using stereotaxic. Experimental groups were: 1. Saline, 2. 6-OHDA, 3. Saline+Training and 4. 6-OHDA+Training (n=8). Training groups 2 weeks after surgery started 14 consecutive days treadmill running. 4 weeks after the induction with 6-OHDA/Saline, mRNA expression levels for PGC-1α , FNDC5 and BDNF were measured through one way ANOVA in the striatum of rats. Results: It was found that exposure to the 6-OHDA (6-OHDA group), resulted in increasing in the Apomorphine-induced rotational asymmetry and significant decrease in mRNAs expression of PGC-1α /FNDC5/BDNF signalling pathway. However, endurance exercise in 6-OHDA+Training group reduces these disorders, significantly (p≤ 0/05). Conclusion: It seems that the endurance Training can reduce behavioral and physiological disorders in Parkinson’ s disease.

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APA: Copy

REZAEE, ZEINAB, MARANDI, SAYED MOHAMMAD, ALAEI, HOJJATALLAH, & ESFARJANI, FAHIMEH. (2019). The Effect of Short Endurance Training on PGC-1α /FNDC5/BDNF Signalling Pathway In 6-OHDA-Induced Parkinson’ s Rats. JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE), 15(29 ), 15-26. SID. https://sid.ir/paper/129561/en

Vancouver: Copy

REZAEE ZEINAB, MARANDI SAYED MOHAMMAD, ALAEI HOJJATALLAH, ESFARJANI FAHIMEH. The Effect of Short Endurance Training on PGC-1α /FNDC5/BDNF Signalling Pathway In 6-OHDA-Induced Parkinson’ s Rats. JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE)[Internet]. 2019;15(29 ):15-26. Available from: https://sid.ir/paper/129561/en

IEEE: Copy

ZEINAB REZAEE, SAYED MOHAMMAD MARANDI, HOJJATALLAH ALAEI, and FAHIMEH ESFARJANI, “The Effect of Short Endurance Training on PGC-1α /FNDC5/BDNF Signalling Pathway In 6-OHDA-Induced Parkinson’ s Rats,” JOURNAL OF APPLIED EXERCISE PHYSIOLOGY (JOURNAL OF SPORTS SCIENCE), vol. 15, no. 29 , pp. 15–26, 2019, [Online]. Available: https://sid.ir/paper/129561/en

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