The Effects of a 4-week Endurance Training on PGC-1α Expression in Adipose Tissue, ANGPTL8 Serum Concentrations and Beta Cells Function of STZ Diabetic Rats

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SADEGHIPOUR H.R.; SALESI M.; RABIEZADEH A.

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Paper Information

Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2019 | Volume:8 | Issue:4 Page(s): 1068-1078

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Title

The Effects of a 4-week Endurance Training on PGC-1α Expression in Adipose Tissue, ANGPTL8 Serum Concentrations and Beta Cells Function of STZ Diabetic Rats

Author(s)

SADEGHIPOUR H.R. | SALESI M. | RABIEZADEH A. | Issue Writer Certificate

Keywords

Endurance TrainingQ1

Beta Cells proliferationQ1

PGC-1αQ1

ANGPTL8Q1

Abstract

Background & Objective: Angiopoietin-like Proteins 8 (ANGPTL8) which is secreted from adipose tissue due to downstream PGC-1α pathways, is the main factor for regeneration of beta cell. The aim of this study was to investigate the effect of a 4-week Endurance Training program on PGC-1α expression in adipose tissue, ANGPTL8 serum concentration and beta cell function (HOMA. B) in diabetic rats. Materials & Methods: Male Wistar rats (N=24) were divided into 3 groups including healthy control (HC), diabetic control (DC) and Endurance Training (ET). After induction of diabetes with STZ, training groups performed 4 weeks of Endurance Training and real-time polymerase chain reaction (Real-Time PCR) method used for the relative expression of PGC-1α in visceral adipose tissue, the enzyme-linked immunosorbent assay (ELISA) method for measuring serum ANGPTL8 levels. Also beta cell number was counted with pancreases hematoxylin-eosin evaluation. Results were analyzed using ANOVA. Results: The relative expression of mRNA PGC-1α was significantly increased in ET (P=0. 001). Although ANGPTL8 levels increased in ET group, this change wasn’ t significant (P=0. 47). HOMA. B didn’ t indicate any significant change in ET (P=. 0. 08) but the number of beta cells in this group significantly increased (P=0. 001). There was a positive correlation between relative mRNA PGC-1α and ANGPTL8 levels. Conclusion: Despite the positive and significant correlation between relative expression of mRNA PGC-1α and ANGPTL8, this increase wasn’ t significant, but this could increases the number of beta cell in Endurance Training group. Further studies with different training programs are recommended.

Cites

Interaction Effect of High Interval and Low Intensity Continuous Trainings with Crocin on the Expressions of PGC-1a and UCP1 in Heart Tissue of Male Diabetic Rats

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APA: Copy

SADEGHIPOUR, H.R., SALESI, M., & RABIEZADEH, A.. (2019). The Effects of a 4-week Endurance Training on PGC-1α Expression in Adipose Tissue, ANGPTL8 Serum Concentrations and Beta Cells Function of STZ Diabetic Rats. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 8(4 ), 1068-1078. SID. https://sid.ir/paper/203978/en

Vancouver: Copy

SADEGHIPOUR H.R., SALESI M., RABIEZADEH A.. The Effects of a 4-week Endurance Training on PGC-1α Expression in Adipose Tissue, ANGPTL8 Serum Concentrations and Beta Cells Function of STZ Diabetic Rats. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2019;8(4 ):1068-1078. Available from: https://sid.ir/paper/203978/en

IEEE: Copy

H.R. SADEGHIPOUR, M. SALESI, and A. RABIEZADEH, “The Effects of a 4-week Endurance Training on PGC-1α Expression in Adipose Tissue, ANGPTL8 Serum Concentrations and Beta Cells Function of STZ Diabetic Rats,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 8, no. 4 , pp. 1068–1078, 2019, [Online]. Available: https://sid.ir/paper/203978/en

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