THE EFFECT OF THE HYDROALCOHOLIC EXTRACT OF ECHIUM AMOENUM ON GLYCEMIC CONTROL AND BODY WEIGHT IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MAHMOUDI MINO; GOLMOHAMMADI HADI; SHAHIDI SIAMAK

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Pars Journal of Medical Sciences Year:2015 | Volume:13 | Issue:1 Page(s): 37-44

Download Full-Text

Persian Verion

View:

12,603

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF THE HYDROALCOHOLIC EXTRACT OF ECHIUM AMOENUM ON GLYCEMIC CONTROL AND BODY WEIGHT IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS

Author(s)

MAHMOUDI MINO | GOLMOHAMMADI HADI | SHAHIDI SIAMAK | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ3

ECHIUM AMOENUMQ2

BLOOD GLUCOSEQ2

STREPTOZOTOCINQ2

RATSQ2

Abstract

Introduction: DIABETES MELLITUS is one of the main metabolic disorders across the world. Numerous medicinal herbs are currently used for the management of DIABETES MELLITUS. The present study was conducted to assess the effect of the hydroalcoholic extract of ECHIUM AMOENUM (EA) on glycemic control and weight in diabetic male RATS.Materials and Methods: The study was conducted on 30 male Wistar RATS randomly divided into five groups of six RATS each, including a control group, a diabetic group receiving no treatments and three diabetic groups treated with 100, 400 or 600 mg/kg of the hydroalcoholic extract of Iranian EA. Diabetes was induced in the RATS by the intraperitoneal administration of a single dose of STREPTOZOTOCIN (60 mg/kg). The RATS' BLOOD GLUCOSE and weight were measured at baseline and then on days 10, 20 and 30 of the study. Their insulin and superoxide dismutase (SOD) activity levels were determined at the end of the study.Results: In all the groups treated with the extract, there was a significant increase in the mean weight and a significant decrease in the mean BLOOD GLUCOSE levels compared to the diabetic group (P<0.05). Insulin levels increased significantly in the RATS treated with a 600 mg/kg dose of the extract compared to the diabetic group. SOD activity also increased significantly in the groups receiving 400 and 600 mg/kg doses of the extract compared to the diabetic group (P<0.05).Conclusion: The study demonstrated that the hydroalcoholic extract of Iranian EA has hypoglycemic effects and can be used to prevent weight loss due to diabetes. These effects might be due to the presence of compounds such as flavonoids and saponins and some of the plant's antioxidant properties.

Cites

No record.

References

No record.

Cite

APA: Copy

MAHMOUDI, MINO, GOLMOHAMMADI, HADI, & SHAHIDI, SIAMAK. (2015). THE EFFECT OF THE HYDROALCOHOLIC EXTRACT OF ECHIUM AMOENUM ON GLYCEMIC CONTROL AND BODY WEIGHT IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 13(1), 37-44. SID. https://sid.ir/paper/130883/en

Vancouver: Copy

MAHMOUDI MINO, GOLMOHAMMADI HADI, SHAHIDI SIAMAK. THE EFFECT OF THE HYDROALCOHOLIC EXTRACT OF ECHIUM AMOENUM ON GLYCEMIC CONTROL AND BODY WEIGHT IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2015;13(1):37-44. Available from: https://sid.ir/paper/130883/en

IEEE: Copy

MINO MAHMOUDI, HADI GOLMOHAMMADI, and SIAMAK SHAHIDI, “THE EFFECT OF THE HYDROALCOHOLIC EXTRACT OF ECHIUM AMOENUM ON GLYCEMIC CONTROL AND BODY WEIGHT IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 13, no. 1, pp. 37–44, 2015, [Online]. Available: https://sid.ir/paper/130883/en

Related Journal Papers