A SURVEY AND COMPARISON OF ET-1 LEVEL IN SCLERODERMA PATIENTS WITH AND WITHOUT PITTING ULCER

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AGHAEI M.; GHARIBDOST F.; ZAYENI H.; AKHLAGHI M.; SEDIGHI S.; ROSTAMIAN A.; AGHDAMI N.; SHOJAA M.

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Journal: Pars Journal of Medical Sciences Year:2011 | Volume:9 | Issue:1 Page(s): 23-27

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Title

A SURVEY AND COMPARISON OF ET-1 LEVEL IN SCLERODERMA PATIENTS WITH AND WITHOUT PITTING ULCER

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Keywords

SYSTEMIC SCLERODERMAQ2

ENDOTHELIN-LQ2

ULCERQ2

Abstract

Introduction: Scleroderma is a systemic disorder with unknown etiology most notably characterized by skin thickening and damage of organs. Endothelin-1 (ET-1) plays a role in skin fibrosis. This study aimed to survey and compare ET-1 level in systematic sclerosis (SSc) patients with and without scar pitting ULCER.Material and Methods: A cross-sectional analytical study was conducted on 95 patients with scleroderma in 2006 who were referred to the Rheumatology Clinic in Shariati hospital of Tehran. A questionnaire was completed and then the level of endothelin I was measured in them. The data were analyzed using SPSS software and statistical tests.Results: The results indicated that the relationship among pitting ULCER, ULCER scar and the level of Endothelin-1 was significant. There was no significant relationship between age and the level of Endothelin-1.Conclusion: These data indicated that the Endothelin-1 plasma level in scleroderma patients with pitting ULCER was higher than patients without pitting ULCER. Thus, increase of ET-1 plasma level could be effective in vascular damage, fibrosis and skin thickness.

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APA: Copy

AGHAEI, M., GHARIBDOST, F., ZAYENI, H., AKHLAGHI, M., SEDIGHI, S., ROSTAMIAN, A., AGHDAMI, N., & SHOJAA, M.. (2011). A SURVEY AND COMPARISON OF ET-1 LEVEL IN SCLERODERMA PATIENTS WITH AND WITHOUT PITTING ULCER. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 9(1), 23-27. SID. https://sid.ir/paper/130894/en

Vancouver: Copy

AGHAEI M., GHARIBDOST F., ZAYENI H., AKHLAGHI M., SEDIGHI S., ROSTAMIAN A., AGHDAMI N., SHOJAA M.. A SURVEY AND COMPARISON OF ET-1 LEVEL IN SCLERODERMA PATIENTS WITH AND WITHOUT PITTING ULCER. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2011;9(1):23-27. Available from: https://sid.ir/paper/130894/en

IEEE: Copy

M. AGHAEI, F. GHARIBDOST, H. ZAYENI, M. AKHLAGHI, S. SEDIGHI, A. ROSTAMIAN, N. AGHDAMI, and M. SHOJAA, “A SURVEY AND COMPARISON OF ET-1 LEVEL IN SCLERODERMA PATIENTS WITH AND WITHOUT PITTING ULCER,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 9, no. 1, pp. 23–27, 2011, [Online]. Available: https://sid.ir/paper/130894/en

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