THE EFFECT OF DEFEROXAMINE ON SURVIVAL OF RATS WITH INDUCED PERITONITIS

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SANIE M.S.; HOSEINIPANAH S.M.; HAJIAN P.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Pars Journal of Medical Sciences Year:2012 | Volume:10 | Issue:1 Page(s): 1-6

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Title

THE EFFECT OF DEFEROXAMINE ON SURVIVAL OF RATS WITH INDUCED PERITONITIS

Author(s)

SANIE M.S. | HOSEINIPANAH S.M. | HAJIAN P. | Issue Writer Certificate

Keywords

DEFEROXAMINEQ3

SURVIVALQ1

RATSQ2

PERITONITISQ3

Abstract

Introduction: Oxidative damage is one of the major factors that lead to cell damage, organ dysfunction and mortality in sepsis. Thus, an attractive candidate for pharmacologic treatment of the septic syndrome is DEFEROXAMINE (DFX), an antioxidant iron chelator used for the removal of iron and a potential free radical scavenger. In this study, the impact of DFX administration on the SURVIVAL of septic animals was evaluated.Material and Methods: Sepsis was induced in 20 RATS, using the Cecal Ligation and Puncture method (CLP) and 10 RATS randomly received subcutaneous DFX (total dose: 40mg/kg) twice and the other 10 RATS received placebo (normal saline). All the RATS had equal health status, environment and nutrition. The time of the death of the RATS was recorded.Results: DEFEROXAMINE increased the SURVIVAL period in RATS and the difference was statistically significant.Conclusion: Treatment with DFX significantly increases the SURVIVAL of septic RATS.

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APA: Copy

SANIE, M.S., HOSEINIPANAH, S.M., & HAJIAN, P.. (2012). THE EFFECT OF DEFEROXAMINE ON SURVIVAL OF RATS WITH INDUCED PERITONITIS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 10(1), 1-6. SID. https://sid.ir/paper/130976/en

Vancouver: Copy

SANIE M.S., HOSEINIPANAH S.M., HAJIAN P.. THE EFFECT OF DEFEROXAMINE ON SURVIVAL OF RATS WITH INDUCED PERITONITIS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2012;10(1):1-6. Available from: https://sid.ir/paper/130976/en

IEEE: Copy

M.S. SANIE, S.M. HOSEINIPANAH, and P. HAJIAN, “THE EFFECT OF DEFEROXAMINE ON SURVIVAL OF RATS WITH INDUCED PERITONITIS,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 10, no. 1, pp. 1–6, 2012, [Online]. Available: https://sid.ir/paper/130976/en

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