THE EFFECT OF AQUEOUS EXTRACT OF DRACOCEPHALUM POLYCHAETUM BURNM ON ULCERATIVE COLITIS IN ADULT MALE RATS

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KOHPYMA HAKIMEH; ABBASNEJAD MAHDI; AHMADINEJAD SAEEDEH; MOSTAFAVI ALI; DERAKHSHANFAR AMIN

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Journal: Pars Journal of Medical Sciences Year:2016 | Volume:14 | Issue:1 Page(s): 9-17

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Title

THE EFFECT OF AQUEOUS EXTRACT OF DRACOCEPHALUM POLYCHAETUM BURNM ON ULCERATIVE COLITIS IN ADULT MALE RATS

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Keywords

ULCERATIVE COLITISQ2

ACETIC ACIDQ2

RATQ2

Abstract

Introduction: ULCERATIVE COLITIS is a chronic inflammatory disease that affects mucosa and submucosa of the colon and rectum. Its etiopathology is attributed to the imbalance of the mucosal immune response to the resident bacterial flora together with genetic and environmental factors. Dracocephalum polychaetum has traditionally been used to treat digestive tract diseases. Therefore, the present study aimed to evaluate the effect of this herbal aqueous extract on ULCERATIVE COLITIS.Materials and Methods: This experimental study was conducted on 48 male Wistar RATs (230-280 g). After inducing ULCERATIVE COLITIS, RATs were divided into the following groups: experimental groups with different doses of extract (50, 100, 200 mg/kg bw), vehicle, prednisolon and control. ULCERATIVE COLITIS was induced through ACETIC ACID 4% enema.Results: The colon weight/length RATio was significantly reduced in the prednisolone group and the extract group at different doses of the extract: 50 mg/kg (P>0.01), 100 mg/kg (P>0.001), and 200 mg/kg (P>0.001) compared with the vehicle group. The severity and extent of inflammation significantly decreased in the extract group at the dose of 200 mg/kg (P>0.05) as compared with the vehicle group.The concentration of malondialdehyde increased in ACETIC ACID-treated groups‚ while it decreased in the groups treated with D. polychaetum extract and prednisolon.).Conclusion: It is concluded that the aqueous extract of D. polychaetum Burnm is effective in treating ACETIC ACIDinduced ULCERATIVE COLITIS.

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APA: Copy

KOHPYMA, HAKIMEH, ABBASNEJAD, MAHDI, AHMADINEJAD, SAEEDEH, MOSTAFAVI, ALI, & DERAKHSHANFAR, AMIN. (2016). THE EFFECT OF AQUEOUS EXTRACT OF DRACOCEPHALUM POLYCHAETUM BURNM ON ULCERATIVE COLITIS IN ADULT MALE RATS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 14(1), 9-17. SID. https://sid.ir/paper/131006/en

Vancouver: Copy

KOHPYMA HAKIMEH, ABBASNEJAD MAHDI, AHMADINEJAD SAEEDEH, MOSTAFAVI ALI, DERAKHSHANFAR AMIN. THE EFFECT OF AQUEOUS EXTRACT OF DRACOCEPHALUM POLYCHAETUM BURNM ON ULCERATIVE COLITIS IN ADULT MALE RATS. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2016;14(1):9-17. Available from: https://sid.ir/paper/131006/en

IEEE: Copy

HAKIMEH KOHPYMA, MAHDI ABBASNEJAD, SAEEDEH AHMADINEJAD, ALI MOSTAFAVI, and AMIN DERAKHSHANFAR, “THE EFFECT OF AQUEOUS EXTRACT OF DRACOCEPHALUM POLYCHAETUM BURNM ON ULCERATIVE COLITIS IN ADULT MALE RATS,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 14, no. 1, pp. 9–17, 2016, [Online]. Available: https://sid.ir/paper/131006/en

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