PHENOTYPIC AND MOLECULAR STUDY OF BETA-LACTAM RESISTANCE IN COAGULASENEGATIVE STAPHYLOCOCCI SAMPLES

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Tahmasebi Hamed; BOKAEIAN MOHAMMAD; Adabi Javad

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Journal: Pars Journal of Medical Sciences Year:2016 | Volume:14 | Issue:1 Page(s): 55-63

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Title

PHENOTYPIC AND MOLECULAR STUDY OF BETA-LACTAM RESISTANCE IN COAGULASENEGATIVE STAPHYLOCOCCI SAMPLES

Author(s)

Tahmasebi Hamed | BOKAEIAN MOHAMMAD | Adabi Javad | Issue Writer Certificate

Keywords

COAGULASE-NEGATIVEQ1

BETA-LACTAMQ2

ANTIBIOTIC RESISTANCEQ2

METHICILLIN RESISTANCEQ2

Abstract

Introduction: The emergence of resistance to BETA-LACTAM antibiotics is one of the most common resistance cases in Staphylococcus, including COAGULASE-NEGATIVE Staphylococcus in hospital pathogens.Therefore, detection of resistance factors can be helpful in treatment process. This study aimed to determine betalactam resistance in COAGULASE-NEGATIVE Staphylococcus by phenotypic and genotypic methods.Materials and Methods: Totally, 710 isolates were collected from clinical samples in health centers of Zahedan. After genus and species of isolates were determined, their sensitivity to 10 BETA-LACTAM antibiotics was measured via disc diffusion method. PCR and specific primers were used to traceblaZ and mec Agens.Results: Of the total samples, 79 isolates were Staphylococcus saprophytic us and 198 isolates were Staphylococcus epidermidis. The resistance profile of the Staphylococcus saprophytic us isolates is as follows: 74 isolates (98.1%) to penicillin, 69 isolates (34.87%) Oxacillin, 31 isolates (24.39%) to ceftriaxone, 71 isolates (87.89%) to Cefoxitin, 43 isolates (43.54%) to cefotaxime, 19 isolates (24.50%) to cefazolin and 27 isolates (17.34%) to cephalexin. PCR results confirmed the presence of mecA and blaZ in most isolates.Conclusion: Given the frequency of mecA and blaZ genes and phenotypic test results in coagulase negative Staphylococcus, resistant to different groups of antibiotics is on the rise.

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APA: Copy

Tahmasebi, Hamed, BOKAEIAN, MOHAMMAD, & Adabi, Javad. (2016). PHENOTYPIC AND MOLECULAR STUDY OF BETA-LACTAM RESISTANCE IN COAGULASENEGATIVE STAPHYLOCOCCI SAMPLES. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 14(1), 55-63. SID. https://sid.ir/paper/131008/en

Vancouver: Copy

Tahmasebi Hamed, BOKAEIAN MOHAMMAD, Adabi Javad. PHENOTYPIC AND MOLECULAR STUDY OF BETA-LACTAM RESISTANCE IN COAGULASENEGATIVE STAPHYLOCOCCI SAMPLES. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2016;14(1):55-63. Available from: https://sid.ir/paper/131008/en

IEEE: Copy

Hamed Tahmasebi, MOHAMMAD BOKAEIAN, and Javad Adabi, “PHENOTYPIC AND MOLECULAR STUDY OF BETA-LACTAM RESISTANCE IN COAGULASENEGATIVE STAPHYLOCOCCI SAMPLES,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 14, no. 1, pp. 55–63, 2016, [Online]. Available: https://sid.ir/paper/131008/en

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