EVALUATION OF DISCRIMINATION INDICES VALIDITY FOR SCREENING OF β-THALASSEMIA TRAIT

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AHMADI AYAT; MIRZAEI KHALILABADI R.A.; NOUROUZI MAHDI; KOHAN N.; RAMZI M.

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2009 | Volume:3 | Issue:3 Page(s): 31-36

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Title

EVALUATION OF DISCRIMINATION INDICES VALIDITY FOR SCREENING OF β-THALASSEMIA TRAIT

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Keywords

BETA - THALASSEMIAQ3

ANEMIAQ3

IRON DEFICIENCYQ3

Abstract

Background and Objectives: b-thalassemia trait (b-TT) and IRON DEFICIENCY ANEMIA (IDA) are the most common forms of microcytic ANEMIA. Screening of b-thalassemia trait is important for medical counseling before marriage and preventing b-thalassemia major birth results. The most common problem in screening -TT is differentiating it from IDA. The aim of this study was to define the sensitivity, specificity, and predictive values of some discrimination indices for screening of b-TT in a sample of such patients.Methods: A total of 82 patients with microcytic ANEMIA (MCV< 80 fl) were selected from Namazi Hospital, Shiraz, Iran, and 9 discrimination indices were calculated for them. The patients were divided intotwo groups: 42 patients with b-TT and 40 patients with IDA. The sensitivity, specificity, positive and negative predictive values and Youden's index of each discrimination index were calculated for screening b-TT.Results: None of the discrimination indices showed 100% of sensitivity and specificity. But the Shin and Lal index, RDW index and RBC count showed the highest and valuable value for screening b-TT.Conclusion: Some discrimination indices like Shin and Lal index, RDW index and RBC index are valuable indices in screening b-TT.

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APA: Copy

AHMADI, AYAT, MIRZAEI KHALILABADI, R.A., NOUROUZI, MAHDI, KOHAN, N., & RAMZI, M.. (2009). EVALUATION OF DISCRIMINATION INDICES VALIDITY FOR SCREENING OF β-THALASSEMIA TRAIT. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 3(3), 31-36. SID. https://sid.ir/paper/131883/en

Vancouver: Copy

AHMADI AYAT, MIRZAEI KHALILABADI R.A., NOUROUZI MAHDI, KOHAN N., RAMZI M.. EVALUATION OF DISCRIMINATION INDICES VALIDITY FOR SCREENING OF β-THALASSEMIA TRAIT. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2009;3(3):31-36. Available from: https://sid.ir/paper/131883/en

IEEE: Copy

AYAT AHMADI, R.A. MIRZAEI KHALILABADI, MAHDI NOUROUZI, N. KOHAN, and M. RAMZI, “EVALUATION OF DISCRIMINATION INDICES VALIDITY FOR SCREENING OF β-THALASSEMIA TRAIT,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 3, no. 3, pp. 31–36, 2009, [Online]. Available: https://sid.ir/paper/131883/en

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