DETECTION AND QUANTIZATION OF THE EXPRESSION OF TWO MU-OPIOID RECEPTOR SPLICE VARIANTS MRNA

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VOUSOOGHI N.; ROUSHAN ZAMIR F.A.; GOUDARZI A.; SEDAGHATI T.; ZARINDAST M.R.; NOURI DALOUEI M.R.

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2008 | Volume:2 | Issue:2 Page(s): 9-14

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Title

DETECTION AND QUANTIZATION OF THE EXPRESSION OF TWO MU-OPIOID RECEPTOR SPLICE VARIANTS MRNA

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Keywords

LYMPHOCYTESQ3

MRNA EXPRESSION PROFILINGQ3

ANALGESISQ3

OPIOIDSQ3

ADDICTIONQ3

MU-OPIOID RECEPTOR SPLICE VARIANTSQ3

Abstract

Background and Objectives: The mu-Opioid receptor (MOR) exerts a critical role on effects of opiodis. The objective of this study is to find a peripheral bio-marker in ADDICTION studies through quantization of the expression of two MOR splice variants mRNA (hMOR-1A and hMOR-1O) in peripheral blood LYMPHOCYTES (PBLs) of long-term abstinent former OPIOIDS addicts.Methods: In this case-control study, case and control people were male and divided in two groups: people who gave up ADDICTION to OPIOIDS (case) and healthy individuals without history of ADDICTION (control). The mRNA expression in PBLs of participants was detected and measured by real-time Polymerase Chain Reaction (PCR) using SYBR Green Dye. Results: The hMOR-1A mRNA expression in PBLs of abstinent group was significantly reduced and reached to 0.33 of the control group (p<0.001). Similar results were obtained for the other splice variant with the mRNA expression of hMOR-1O in PBLs of abstinent group reaching to 0.38 of that of the control group (p < 0.001).Conclusions: mRNA expression deficiency of two MU-OPIOID RECEPTOR SPLICE VARIANTS, hMOR-1A and nMOR-1O, seams to be a risk factor making individuals vulnerable to drug ADDICTION. Based on this analysis measuring the amount of mRNA expression of these two splice variants in PBLs can serve as a peripheral biomarker for detecting people at risk.

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APA: Copy

VOUSOOGHI, N., ROUSHAN ZAMIR, F.A., GOUDARZI, A., SEDAGHATI, T., ZARINDAST, M.R., & NOURI DALOUEI, M.R.. (2008). DETECTION AND QUANTIZATION OF THE EXPRESSION OF TWO MU-OPIOID RECEPTOR SPLICE VARIANTS MRNA. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 2(2), 9-14. SID. https://sid.ir/paper/132160/en

Vancouver: Copy

VOUSOOGHI N., ROUSHAN ZAMIR F.A., GOUDARZI A., SEDAGHATI T., ZARINDAST M.R., NOURI DALOUEI M.R.. DETECTION AND QUANTIZATION OF THE EXPRESSION OF TWO MU-OPIOID RECEPTOR SPLICE VARIANTS MRNA. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2008;2(2):9-14. Available from: https://sid.ir/paper/132160/en

IEEE: Copy

N. VOUSOOGHI, F.A. ROUSHAN ZAMIR, A. GOUDARZI, T. SEDAGHATI, M.R. ZARINDAST, and M.R. NOURI DALOUEI, “DETECTION AND QUANTIZATION OF THE EXPRESSION OF TWO MU-OPIOID RECEPTOR SPLICE VARIANTS MRNA,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 2, no. 2, pp. 9–14, 2008, [Online]. Available: https://sid.ir/paper/132160/en

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