INVOLVEMENT OF OPIOID RECEPTORS IN THE ANTICONVULSANT EFFECT OF PROGESTERONE IN OVARIECTOMIZED MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHAJEHPOUR L.; NAJAFZADEH VARZI H.; HASANVAND F.; KESMATI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Arak University Medical Sciences Year:2013 | Volume:16 | Issue:2 (71) Page(s): 20-28

Download Full-Text

Persian Verion

View:

646

Download:

Cites:

Information Journal Paper

Title

INVOLVEMENT OF OPIOID RECEPTORS IN THE ANTICONVULSANT EFFECT OF PROGESTERONE IN OVARIECTOMIZED MICE

Author(s)

KHAJEHPOUR L. | NAJAFZADEH VARZI H. | HASANVAND F. | KESMATI M. | Issue Writer Certificate

Keywords

CONVULSIONQ2

OPIOID RECEPTORSQ2

PROGESTERONEQ2

Abstract

Background: PROGESTERONE is a female steroid hormone that has a potent anticonvulsant effect on human and animal. The aim of this study was to investigate the involvement of OPIOID RECEPTORS in the anticonvulsant effect of PROGESTERONE on ovariectomized mice.Materials and Methods: In this experimental study, all animals were ovariectomized. After two weeks, they received an intraperitoneal (i.p.) injection of drugs (progesterone and naloxone) or saline. The animals also received a subcutaneous injection of strychnine for induction of convulsive seizures, 30 minutes after administration of drugs or saline. For evaluation of CONVULSION in the animals, CONVULSION onset time, CONVULSION duration, the number of seizures, and death time were recorded.Results: PROGESTERONE (25 and 50 mg/kg, i.p.) decreased the strychnine-induced CONVULSION.The anticonvulsant effect of 50 mg/kg of PROGESTERONE was abolished by naloxone (5 mg/kg, i.p.) injection, whereas administration of the same doses of naloxone alone did not affect strychnineinduced CONVULSION.Conclusion: These results suggest that OPIOID RECEPTORS may play an important role in the anticonvulsant effect of PROGESTERONE.

Cites

No record.

References

Cite

APA: Copy

KHAJEHPOUR, L., NAJAFZADEH VARZI, H., HASANVAND, F., & KESMATI, M.. (2013). INVOLVEMENT OF OPIOID RECEPTORS IN THE ANTICONVULSANT EFFECT OF PROGESTERONE IN OVARIECTOMIZED MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 16(2 (71)), 20-28. SID. https://sid.ir/paper/69538/en

Vancouver: Copy

KHAJEHPOUR L., NAJAFZADEH VARZI H., HASANVAND F., KESMATI M.. INVOLVEMENT OF OPIOID RECEPTORS IN THE ANTICONVULSANT EFFECT OF PROGESTERONE IN OVARIECTOMIZED MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2013;16(2 (71)):20-28. Available from: https://sid.ir/paper/69538/en

IEEE: Copy

L. KHAJEHPOUR, H. NAJAFZADEH VARZI, F. HASANVAND, and M. KESMATI, “INVOLVEMENT OF OPIOID RECEPTORS IN THE ANTICONVULSANT EFFECT OF PROGESTERONE IN OVARIECTOMIZED MICE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 16, no. 2 (71), pp. 20–28, 2013, [Online]. Available: https://sid.ir/paper/69538/en

Related Journal Papers