THE EFFECT OF ATORVASTATIN ON OXIDATIVE STRESS AND RENAL FUNCTION IN EXPERIMENTAL MODEL OF DIABETIC NEPHROPATHY

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FAGHIHI NASTARAN; MOHAMMADI MOHAMMAD TAGHI; EIDI AKRAM

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2016 | Volume:9 | Issue:11 Page(s): 1-11

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Title

THE EFFECT OF ATORVASTATIN ON OXIDATIVE STRESS AND RENAL FUNCTION IN EXPERIMENTAL MODEL OF DIABETIC NEPHROPATHY

Author(s)

FAGHIHI NASTARAN | MOHAMMADI MOHAMMAD TAGHI | EIDI AKRAM | Issue Writer Certificate

Keywords

DIABETIC NEPHROPATHYQ2

ATORVASTATINQ2

HYPERGLYCEMIAQ2

OXIDATIVE STRESSQ2

Abstract

Background and Objectives: ATORVASTATIN has multiple effects independent of lipid lowering, such as anti-inflammatory and antioxidant. The present study was performed with the purpose of determining the effect of ATORVASTATIN on renal function and OXIDATIVE STRESS response in experimental model of DIABETIC NEPHROPATHY.Methods: In an experimental study, male Wistar rats were randomly divided into four groups (N=24): normal, normal treatment, diabetic, diabetic treatment. The rats were made diabetic by an intravenous injection of streptozotocin (40 mg/kg) and the treated rats received ATORVASTATIN for 8 weeks (at dose of 40 mg/kg/day). At the end of the experiment, blood samples were collected to measure glucose and creatinine levels. The concentration of malondialdehyde (MDA) and the activity of renal catalase were assessed.Results: Chronic uncontrolled HYPERGLYCEMIA (blood glucose& gt; 500mg/dl) significantly increased the blood creatinine in diabetic group (1.70±0.30mg/dl) compared to normal animals (0.40±0.07mg/dl), (p& lt; 0.05). Also, HYPERGLYCEMIA caused a decrease in the activity of catalase enzyme (57%) along with an increase in the MDA concentration (0.15±0.02nmol/mg protein) compared to normal group (0.04±0.02nmol/mg protein). ATORVASTATIN significantly decreased the blood creatinine of diabetic animals (0.70±0.20mg/dl) compared to normal group (p& lt; 0.05). Finally, in the treated diabetic animals, renal activity of catalase enzyme increased (52%) and MDA concentration decreased (0.03±0.01nmol/mg protein).Conclusion: The findings of this study indicated that ATORVASTATIN is able to strengthen the renal antioxidant system during DIABETIC NEPHROPATHY. Therefore, it appears that ATORVASTATIN prevents HYPERGLYCEMIA-induced nephropathy through the inhibition of free radical production.

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APA: Copy

FAGHIHI, NASTARAN, MOHAMMADI, MOHAMMAD TAGHI, & EIDI, AKRAM. (2016). THE EFFECT OF ATORVASTATIN ON OXIDATIVE STRESS AND RENAL FUNCTION IN EXPERIMENTAL MODEL OF DIABETIC NEPHROPATHY. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 9(11), 1-11. SID. https://sid.ir/paper/132332/en

Vancouver: Copy

FAGHIHI NASTARAN, MOHAMMADI MOHAMMAD TAGHI, EIDI AKRAM. THE EFFECT OF ATORVASTATIN ON OXIDATIVE STRESS AND RENAL FUNCTION IN EXPERIMENTAL MODEL OF DIABETIC NEPHROPATHY. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2016;9(11):1-11. Available from: https://sid.ir/paper/132332/en

IEEE: Copy

NASTARAN FAGHIHI, MOHAMMAD TAGHI MOHAMMADI, and AKRAM EIDI, “THE EFFECT OF ATORVASTATIN ON OXIDATIVE STRESS AND RENAL FUNCTION IN EXPERIMENTAL MODEL OF DIABETIC NEPHROPATHY,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 9, no. 11, pp. 1–11, 2016, [Online]. Available: https://sid.ir/paper/132332/en

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