Effect of combined Atorvastatin and zinc oxide on the biochemical and histopathological alterations in kidney of diabetic rats

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Karampour Gebchag Zahra; HEIDARI REZA; ABTAHI FROUSHANI SEYYED MEYSAM; FAROKHI FARAH

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Journal: Journal of Gorgan University of Medical Sciences Year:2019 | Volume:21 | Issue:2 (70) Page(s): 9-17

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Title

Effect of combined Atorvastatin and zinc oxide on the biochemical and histopathological alterations in kidney of diabetic rats

Author(s)

Karampour Gebchag Zahra | HEIDARI REZA | ABTAHI FROUSHANI SEYYED MEYSAM | FAROKHI FARAH | Issue Writer Certificate

Keywords

Diabetes mellitusQ2

Diabetic nephropathyQ2

AtorvastatinQ2

Zinc oxideQ2

RatQ2

Abstract

Background and Objective: Diabetic mellitus nephropathy is one of the most important implication factors in kidney´ s physiological function in Diabetes mellitus. Having major role in filtRation, in hyperglycemic condition kidney has shown more damages in comparison with other tissues. This study was done to determine the effect of combined Atorvastatin and Zinc oxide on the biochemical and histopathological alteRations in kidney of diabetic Rats. Methods: In this experimental study, 40 female Wistar Rats were randomly allocated into five groups including normal control (NC), diabetic control (DC), diabetic Rats treated with Atorvastatin (20mg/kg/bw daily, orally) (D+A), Zinc oxide (30mg/kg/bw daily, orally) (D+Z) and combination of each drug in half dose (daily, orally) (D+A+Z). Diabetes induced in Rats by a single intraperitoneal injection of 60mg/kg/bw streptozotocin-diabetic. Animals treated for one month. At the end of the study, kidney weight and body weight and biochemical factors including creatinine and urea were measured to assess renal function. For determing the histopathology of kidney tissue, sections with 4-5 micrometer were stained with hematoxylin and eosin. Results: The level of serum creatinine and urea was significantly increased in diabetic Rats in compare to controls (P<0. 05). Treatment of diabetic Rats with half doses of combination of Atorvastatin and Zinc oxide reduced the level of creatinine, urea and renal tissue damage in comparision with diabetic Rats without treatment (P<0. 05). Conclusion: This study showed that the combination of Atorvastatin and Zinc oxide has effect on controlling Diabetic nephropathy.

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APA: Copy

Karampour Gebchag, Zahra, HEIDARI, REZA, ABTAHI FROUSHANI, SEYYED MEYSAM, & FAROKHI, FARAH. (2019). Effect of combined Atorvastatin and zinc oxide on the biochemical and histopathological alterations in kidney of diabetic rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 21(2 (70) ), 9-17. SID. https://sid.ir/paper/368400/en

Vancouver: Copy

Karampour Gebchag Zahra, HEIDARI REZA, ABTAHI FROUSHANI SEYYED MEYSAM, FAROKHI FARAH. Effect of combined Atorvastatin and zinc oxide on the biochemical and histopathological alterations in kidney of diabetic rats. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;21(2 (70) ):9-17. Available from: https://sid.ir/paper/368400/en

IEEE: Copy

Zahra Karampour Gebchag, REZA HEIDARI, SEYYED MEYSAM ABTAHI FROUSHANI, and FARAH FAROKHI, “Effect of combined Atorvastatin and zinc oxide on the biochemical and histopathological alterations in kidney of diabetic rats,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 2 (70) , pp. 9–17, 2019, [Online]. Available: https://sid.ir/paper/368400/en

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