THE EFFECT OF HYDROALCOHOLIC EXTRACT OF ANETHUM GRAVEOLENS (DILL) ON SERUM ESTROGEN AND PROGESTERONE LEVEL IN FEMALE RATS

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HEIDARIFAR REZA; FARAHANI HAMID; MIRIZADEH MARYAM; YOUSEFI ALI; DOLATSHAHI MOJTABA; KAZEMIAN MANSOURABAD MOSTAFA; MOHEBBI ERFAN; HEIDARI HAMID; KHOSHNEJAD FAHIMEH; YAZDANDOOST MONIREH

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2015 | Volume:9 | Issue:5 Page(s): 42-49

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Title

THE EFFECT OF HYDROALCOHOLIC EXTRACT OF ANETHUM GRAVEOLENS (DILL) ON SERUM ESTROGEN AND PROGESTERONE LEVEL IN FEMALE RATS

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ANETHUM GRAVEOLENSQ2

ESTROGENSQ2

PROGESTERONEQ3

RATSQ2

Abstract

Background and Objectives: ANETHUM GRAVEOLENS (Dill) like Bunium persicum has therapeutic effect, such as food digestive, carminative, anticonvulsant, but its effect on increasing milk is certain. In this study, the possible effect of hydroalcoholic extract of Dill was investigated on serum levels of estrogen and PROGESTERONE in female RATS.Methods: The present study was carried out on 36 mature female wistar RATS (weight, 150-250g) in 4 groups (9 RATS per group):The first and second groups received the hydroalcoholic extract at doses of 50 and 100mg/kg, respectively, and the third group (sham) received 1 ml of water (solvent)for 14 days through gavage. The fourth group (control) received no drug. At the end, a deep ether anesthesia and blood sampling from the heart of animals were done and the serum levels of estrogen and PROGESTERONE hormones were measured. The results were compared using one-way ANOVA statistical test. The significance level was considered to be p<0.05.Results: The serum concentration of PROGESTERONE hormone significantly increased in groups received the extract compared to the control and sham groups (p<0.05). But the serum level of estrogen did not show any significant difference in experimental groups compared to the control group.Conclusion: The results of this study indicated that the hydroalcoholic extract of dill seed at both doses could be effective in the increase of serum PROGESTERONE level. Therefore, in future, after conducting more studies, this extract should be considered as an important factor for elevation of this hormone level in women.

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APA: Copy

HEIDARIFAR, REZA, FARAHANI, HAMID, MIRIZADEH, MARYAM, YOUSEFI, ALI, DOLATSHAHI, MOJTABA, KAZEMIAN MANSOURABAD, MOSTAFA, MOHEBBI, ERFAN, HEIDARI, HAMID, KHOSHNEJAD, FAHIMEH, & YAZDANDOOST, MONIREH. (2015). THE EFFECT OF HYDROALCOHOLIC EXTRACT OF ANETHUM GRAVEOLENS (DILL) ON SERUM ESTROGEN AND PROGESTERONE LEVEL IN FEMALE RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 9(5), 42-49. SID. https://sid.ir/paper/132339/en

Vancouver: Copy

HEIDARIFAR REZA, FARAHANI HAMID, MIRIZADEH MARYAM, YOUSEFI ALI, DOLATSHAHI MOJTABA, KAZEMIAN MANSOURABAD MOSTAFA, MOHEBBI ERFAN, HEIDARI HAMID, KHOSHNEJAD FAHIMEH, YAZDANDOOST MONIREH. THE EFFECT OF HYDROALCOHOLIC EXTRACT OF ANETHUM GRAVEOLENS (DILL) ON SERUM ESTROGEN AND PROGESTERONE LEVEL IN FEMALE RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2015;9(5):42-49. Available from: https://sid.ir/paper/132339/en

IEEE: Copy

REZA HEIDARIFAR, HAMID FARAHANI, MARYAM MIRIZADEH, ALI YOUSEFI, MOJTABA DOLATSHAHI, MOSTAFA KAZEMIAN MANSOURABAD, ERFAN MOHEBBI, HAMID HEIDARI, FAHIMEH KHOSHNEJAD, and MONIREH YAZDANDOOST, “THE EFFECT OF HYDROALCOHOLIC EXTRACT OF ANETHUM GRAVEOLENS (DILL) ON SERUM ESTROGEN AND PROGESTERONE LEVEL IN FEMALE RATS,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 9, no. 5, pp. 42–49, 2015, [Online]. Available: https://sid.ir/paper/132339/en

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