THE EFFECTS OF FGF8 AND SHH ON EXPRESSION OF DOPAMINERGIC MARKERS FROM HUMAN AMNIOTIC EPITHELIAL CELLS

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NIKNEZHAD HASAN; PEYROVI HABIB ELAH; AHMADIANI A.A.H.; JORJANI M.

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Title

THE EFFECTS OF FGF8 AND SHH ON EXPRESSION OF DOPAMINERGIC MARKERS FROM HUMAN AMNIOTIC EPITHELIAL CELLS

Author(s)

NIKNEZHAD HASAN | PEYROVI HABIB ELAH | AHMADIANI A.A.H. | JORJANI M. | Issue Writer Certificate

Keywords

AMNIONQ3

EPITHELIAL CELLSQ3

NEURONSQ3

DOPAMINEQ3

FGF8Q3

SHHQ3

Abstract

Background and Objectives: Recently, interest has increased in the potential employment of embryonic stem cells for the treatment of Parkinson's disease, which has been considered as an alternative therapeutic strategy. Due to their pluripotent differentiation potential, the finding that they do not induce carcinoma and the fact that they do not raise the ethical concerns connected with human embryonic stem cells, human amniotic EPITHELIAL CELLS are considered to be a very promising cell source. The aim of this study was to investigate the effects of FGF8 and SHH on the expression of DOPAMINErgic markers from human amniotic EPITHELIAL CELLS. Methods: In this study, we examined the differentiation of DOPAMINErgic NEURONS in vitro from AECs using the expression of several markers including TH, DAT and DbH. For DOPAMINErgic differentiation, sonic hedgehog (Shh) and FGF8 were added to cultures and the cultures were allowed to differentiate for 21 days. Analysis of AECs derived DOPAMINErgic NEURONS was performed at the TH, DAT, b-tubulin III and DbH expression levels by immunocitochemistry. The significance of the data was tested by Student's t-test (between two groups) and one-way analysis of variance (ANOVA) followed by Tukey post-test.

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APA: Copy

NIKNEZHAD, HASAN, PEYROVI, HABIB ELAH, AHMADIANI, A.A.H., & JORJANI, M.. (2011). THE EFFECTS OF FGF8 AND SHH ON EXPRESSION OF DOPAMINERGIC MARKERS FROM HUMAN AMNIOTIC EPITHELIAL CELLS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 4(4), 37-47. SID. https://sid.ir/paper/132401/en

Vancouver: Copy

NIKNEZHAD HASAN, PEYROVI HABIB ELAH, AHMADIANI A.A.H., JORJANI M.. THE EFFECTS OF FGF8 AND SHH ON EXPRESSION OF DOPAMINERGIC MARKERS FROM HUMAN AMNIOTIC EPITHELIAL CELLS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2011;4(4):37-47. Available from: https://sid.ir/paper/132401/en

IEEE: Copy

HASAN NIKNEZHAD, HABIB ELAH PEYROVI, A.A.H. AHMADIANI, and M. JORJANI, “THE EFFECTS OF FGF8 AND SHH ON EXPRESSION OF DOPAMINERGIC MARKERS FROM HUMAN AMNIOTIC EPITHELIAL CELLS,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 4, no. 4, pp. 37–47, 2011, [Online]. Available: https://sid.ir/paper/132401/en

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