COMPARISON OF ANTIMICROBIAL EFFECT OF FREE AND LIPOSOMAL AMIKACIN AGAINST PSEUDOMONAS AERUGINOSA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MIRZAEI MOHSEN; GHARIB AMIR; OULIA P.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2008 | Volume:2 | Issue:2 Page(s): 43-48

Download Full-Text

Persian Verion

View:

800

Download:

Cites:

Information Journal Paper

Title

COMPARISON OF ANTIMICROBIAL EFFECT OF FREE AND LIPOSOMAL AMIKACIN AGAINST PSEUDOMONAS AERUGINOSA

Author(s)

MIRZAEI MOHSEN | GHARIB AMIR | OULIA P. | Issue Writer Certificate

Keywords

PSEUDOMONAS AERUGINOSAQ4

AMIKACINQ4

LIPOSOMQ3

Abstract

Background and objectives: PSEUDOMONAS AERUGINOSA is important opportunistic pathogen and to produce widespread infection by numerous virulence factors. Drug delivery system that reduces the drugs toxicity while increasing their therapeutic index is a great interest and LIPOSOMes can provide the benefits. LIPOSOMes are colloidal vesicules ranging from a few nanometers to several micrometers in diameter. The present in vitro study was designated to evaluate the antimicrobial activity of free and LIPOSOMal AMIKACIN against PSEUDOMONAS AERUGINOSA (ATCC 27853).Materials and methods: The minimal inhibitory concentrations (MICs) of free and LIPOSOMal AMIKACIN for PSEUDOMONAS AERUGINOSA (ATCC 27853) were determined by broth macro-dilution technique as recommended by CLSI (Clinical and laboratory standards institute). We therefore, encapsulated this drug in to LIPOSOMe prepared by sonication. Change of number of bacteria in equal minimal inhibitory concentration of LIPOSOMal AMIKACIN was compared with the change of number of bacteria in the present of various concentrations of free AMIKACIN.Results: The results showed that of LIPOSOMal AMIKACIN had antimicrobial effect and MIC of LIPOSOMal AMIKACIN were equal of 4mg/ml however minimal inhibitory concentration of free AMIKACIN was 2mg/ml. Comparison of change of number of bacteria had shown that the effect of LIPOSOMal AMIKACIN (4mg/ml) after 8h is equal of 6mg/ml free AMIKACIN after 4h.Conclusion: According to the results we can probably to use of LIPOSOMal AMIKACIN for Pseudomonas infections, but we need more study and research

Cites

No record.

References

No record.

Cite

APA: Copy

MIRZAEI, MOHSEN, GHARIB, AMIR, & OULIA, P.. (2008). COMPARISON OF ANTIMICROBIAL EFFECT OF FREE AND LIPOSOMAL AMIKACIN AGAINST PSEUDOMONAS AERUGINOSA. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 2(2), 43-48. SID. https://sid.ir/paper/132614/en

Vancouver: Copy

MIRZAEI MOHSEN, GHARIB AMIR, OULIA P.. COMPARISON OF ANTIMICROBIAL EFFECT OF FREE AND LIPOSOMAL AMIKACIN AGAINST PSEUDOMONAS AERUGINOSA. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2008;2(2):43-48. Available from: https://sid.ir/paper/132614/en

IEEE: Copy

MOHSEN MIRZAEI, AMIR GHARIB, and P. OULIA, “COMPARISON OF ANTIMICROBIAL EFFECT OF FREE AND LIPOSOMAL AMIKACIN AGAINST PSEUDOMONAS AERUGINOSA,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 2, no. 2, pp. 43–48, 2008, [Online]. Available: https://sid.ir/paper/132614/en

Related Journal Papers