ANTIBACTERIAL ACTIVITY AND EFFICIENT SYNTHESIS OF 3,4 DIHYDROPYRANO [C] CHROMENE DERIVATIVES BY USING AMMONIUM TRIFLUOROACETATE (CF3COONH4) CATALYST

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MONTAZERI NASER

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Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2017 | Volume:11 | Issue:2 Page(s): 61-68

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Title

ANTIBACTERIAL ACTIVITY AND EFFICIENT SYNTHESIS OF 3,4 DIHYDROPYRANO [C] CHROMENE DERIVATIVES BY USING AMMONIUM TRIFLUOROACETATE (CF3COONH4) CATALYST

Author(s)

MONTAZERI NASER | Issue Writer Certificate

Keywords

ANTIMICROBIAL ACTIVITYQ1

GRAM-POSITIVE BACTERIAQ2

GRAM-NEGATIVE BACTERIAQ2

4-HYDROXYCOUMARINQ2

AMMONIUM TRIFLUOROACETATEQ2

Abstract

Background and Aims: In this research, we present a three-component method for the preparation of 3, 4-dihydropyrano [c] chromene derivatives in the presence of AMMONIUM TRIFLUOROACETATE. All the compounds were evaluated for their in vitro ANTIMICROBIAL ACTIVITY against different bacterial strains. Antibacterial behavior of product was studied based on reference Gram-positive and Gram- negative bacteria.Materials and Methods: 3, 4-Dihydropyrano [c] chromenes were synthesized using an efficient condensation of 4-HYDROXYCOUMARIN, aryl aldehydes and malononitrile catalyzed by AMMONIUM TRIFLUOROACETATE. Different concentrations of analogs and positive control drugs were prepared in DMSO. Inoculums and sterile water were added to the fourteen test tubes each containing 1 mL of test solution at different concentrations. The tubes were incubated for 24h at 37oC. After the incubation time, the ANTIMICROBIAL ACTIVITY was carefully evaluated.Results: In an optimized reaction condition, the products 4a-j were obtained in high yields under reflux conditions. The antimicrobial screening data revealed that the compounds 4b and 4e have shown good activity against Gram-negative Escherichia spp.Conclusions: Present methodology offers several advantages such as short reaction time, simple procedure with an easy work-up and mild reaction conditions. We anticipated that the present method will receive the attention of medicinal chemists and be used for elaborate synthesis and pharmaceutical screening of chromenes based molecules.

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APA: Copy

MONTAZERI, NASER. (2017). ANTIBACTERIAL ACTIVITY AND EFFICIENT SYNTHESIS OF 3,4 DIHYDROPYRANO [C] CHROMENE DERIVATIVES BY USING AMMONIUM TRIFLUOROACETATE (CF₃COONH₄) CATALYST. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 11(2), 61-68. SID. https://sid.ir/paper/132631/en

Vancouver: Copy

MONTAZERI NASER. ANTIBACTERIAL ACTIVITY AND EFFICIENT SYNTHESIS OF 3,4 DIHYDROPYRANO [C] CHROMENE DERIVATIVES BY USING AMMONIUM TRIFLUOROACETATE (CF₃COONH₄) CATALYST. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2017;11(2):61-68. Available from: https://sid.ir/paper/132631/en

IEEE: Copy

NASER MONTAZERI, “ANTIBACTERIAL ACTIVITY AND EFFICIENT SYNTHESIS OF 3,4 DIHYDROPYRANO [C] CHROMENE DERIVATIVES BY USING AMMONIUM TRIFLUOROACETATE (CF₃COONH₄) CATALYST,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 11, no. 2, pp. 61–68, 2017, [Online]. Available: https://sid.ir/paper/132631/en

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