STUDY OF DRUG RESISTANCE AND OMPA GENE EXISTENCE IN CLINICAL ACINETOBACTER BAUMANNII ISOLATES

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BABAPOUR EBRAHIM; HADDADI AZAM; MIRNEJAD REZA; ANGAJI SEYED ABDOLHAMID; AMIRMOZAFARI NOUR

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2017 | Volume:11 | Issue:1 Page(s): 30-38

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Information Journal Paper

Title

STUDY OF DRUG RESISTANCE AND OMPA GENE EXISTENCE IN CLINICAL ACINETOBACTER BAUMANNII ISOLATES

Author(s)

Keywords

ACINETOBACTER BAUMANNIIQ2

MULTI DRUG RESISTANCEQ2

OMPA GENEQ2

Abstract

Background and Aim: ACINETOBACTER BAUMANNII is one of the most important multi drugresistant species associated with nosocomial infections. Several factors involve in resistance to drug and its pathogenicity. Of these factors, OmpA protein plays a crucial role. Therefore, the aim of current research was to assess resistance to drug and alsoomp A gene existence in A. baumanniiisolated from clinical sources.Materials and Methods: Firstly, clinical samples were collected from Imam Khomeini, Milad and Motahari Hospitals during 2015-2016 years and the final confirmation were done by using biochemical methods. Afterwards, susceptibilities to antibiotics of different classes were determined by disc diffusion method and presence ofompA gene was checked by using PCR method and verified by sequencing.Results: The results show that of 650 clinical samples, 156 (24%) of isolates were formed ofA. baumannii and mostly showed resistance to different classes of antibiotics.92.95% of isolates were MULTI DRUG RESISTANCE (MDR) and finally 86.53% were extremely drug resistance (XDR). All of them containedomp A gene.Conclusions: Existence of MULTI DRUG RESISTANCE in most isolates as well as presence of ompAin all samples can cause bacterial virulence and drug resistance. It seems essential to provide continuous monitoring and determination of antibiotic susceptibility of clinical A. baumannii, decrease the moral and material damage caused by the bacteria.

Cites

Prevalence of Imipenem-Resistant Acinetobacter baumannii isolates in Iran: A Meta-Analysis

References

IDENTIFICATION OF FIVE PHYLOGENIC GROUPS OF CARBAPENEMASE (BLA OXA-23,24,51,58,143) IN ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM CLINICAL SAMPLES IN IRAN BY MULTIPLEX PCR

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APA: Copy

BABAPOUR, EBRAHIM, HADDADI, AZAM, MIRNEJAD, REZA, ANGAJI, SEYED ABDOLHAMID, & AMIRMOZAFARI, NOUR. (2017). STUDY OF DRUG RESISTANCE AND OMPA GENE EXISTENCE IN CLINICAL ACINETOBACTER BAUMANNII ISOLATES. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 11(1), 30-38. SID. https://sid.ir/paper/132716/en

Vancouver: Copy

BABAPOUR EBRAHIM, HADDADI AZAM, MIRNEJAD REZA, ANGAJI SEYED ABDOLHAMID, AMIRMOZAFARI NOUR. STUDY OF DRUG RESISTANCE AND OMPA GENE EXISTENCE IN CLINICAL ACINETOBACTER BAUMANNII ISOLATES. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2017;11(1):30-38. Available from: https://sid.ir/paper/132716/en

IEEE: Copy

EBRAHIM BABAPOUR, AZAM HADDADI, REZA MIRNEJAD, SEYED ABDOLHAMID ANGAJI, and NOUR AMIRMOZAFARI, “STUDY OF DRUG RESISTANCE AND OMPA GENE EXISTENCE IN CLINICAL ACINETOBACTER BAUMANNII ISOLATES,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 11, no. 1, pp. 30–38, 2017, [Online]. Available: https://sid.ir/paper/132716/en

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