ANTIBIOTIC RESISTANCE PATTERN AMONG NONFERMENTING GRAM-NEGATIVE BACTERIA ISOLATED FROM CLINICAL SPECIMENS DURING 2007-2008 IN KERMAN, IRAN

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RAZAVI M.; MANSOURI SH.; NOROUZI F.

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Journal: IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY Year:2011 | Volume:4 | Issue:4 Page(s): 7-13

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Title

ANTIBIOTIC RESISTANCE PATTERN AMONG NONFERMENTING GRAM-NEGATIVE BACTERIA ISOLATED FROM CLINICAL SPECIMENS DURING 2007-2008 IN KERMAN, IRAN

Author(s)

RAZAVI M. | MANSOURI SH. | NOROUZI F. | Issue Writer Certificate

Keywords

NONFERMENTING GRAM-NEGATIVE BACTERIAQ4

NITROCEFINQ4

EXTENDED-SPECTRUM β- LACTAMASESQ4

KERMANQ3

Abstract

Background: NONFERMENTING GRAM-NEGATIVE BACTERIA (NFGNB) are opportunistic pathogens responsible for many nosocomial infections. The most prevalent NFGNB species are Pseudomonas aeruginosa, Acinetobacter baumannii, Stenotrophomonas maltophilia. These bacteria expressed high level of resistance to antibiotics usually through the most general mechanism of resistance by production of Extended-Spectrum b-Iactamases (ESBLs). The present study was conducted to determine the prevalence rate of NFGNB, their antibiotic resistances and ESBLs production during 2007-2008 in KERMAN.Material and Methods: A total of 110 NFGNB isolates from hospitalized patients and outpatients (Afzali Poor, Bahonar, and Shafa hospitals) were collected during 2007-2008 in KERMAN. The isolates were identified by biochemical methods as 93 isolates (84.5%) of Pseudomonas aeruginosa, 11 isolates (10%) of Stenotrophomonas maltophilia and 6 isolates (5.5%) of Acinetobacter baumannii. The minimum inhibitory concentrations (Mles) of the isolates to 11 common antibiotics were determined using agar dilution method. These isolates are capable of producing b-Iactamase, and they were determined using NITROCEFIN disks. The ESBL producing isolates were detected by DCDT method (double disk test & combined disk test).Results: p. aeruginosa was the most common isolate among all isolated NFGNB. Resistance to cefotaxime, ceftizoxime, nalidixic acid, amoxicillin, cephalexin, for all the isolates was very high (74-100%), whereas the lowest rate of resistance was observed against imipenem, ceftazidime and ciprofloxacin with the rate of 0.9%, 13.6% and 24.5% respectively. b-Iactamase production was positive for 50 (45.5%) of the isolate and 47.2% of the isolate were ESBL producers. Antibiotic resistance, b-Iactamase and ESBL production were more common in Acinetobacter baumannii isolates.Conclusion: NFGNB, especially Acinetobacter baumannii , showed high antibiotic resistance to common drugs. Ceftazidime and imipenem are still useful antibiotics and they can be used for the treatment of infections caused by these bacteria.

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References

THE PREVALENCE OF MULTI-RESISTANT PSEUDOMONAS AERUGINOSA AND ACINETOBACTER SPP. IN PATIENTS ADDMITED IN BAQIYATALLAH HOSPITAL IN 2005

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APA: Copy

RAZAVI, M., MANSOURI, SH., & NOROUZI, F.. (2011). ANTIBIOTIC RESISTANCE PATTERN AMONG NONFERMENTING GRAM-NEGATIVE BACTERIA ISOLATED FROM CLINICAL SPECIMENS DURING 2007-2008 IN KERMAN, IRAN. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, 4(4), 7-13. SID. https://sid.ir/paper/132737/en

Vancouver: Copy

RAZAVI M., MANSOURI SH., NOROUZI F.. ANTIBIOTIC RESISTANCE PATTERN AMONG NONFERMENTING GRAM-NEGATIVE BACTERIA ISOLATED FROM CLINICAL SPECIMENS DURING 2007-2008 IN KERMAN, IRAN. IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY[Internet]. 2011;4(4):7-13. Available from: https://sid.ir/paper/132737/en

IEEE: Copy

M. RAZAVI, SH. MANSOURI, and F. NOROUZI, “ANTIBIOTIC RESISTANCE PATTERN AMONG NONFERMENTING GRAM-NEGATIVE BACTERIA ISOLATED FROM CLINICAL SPECIMENS DURING 2007-2008 IN KERMAN, IRAN,” IRANIAN JOURNAL OF MEDICAL MICROBIOLOGY, vol. 4, no. 4, pp. 7–13, 2011, [Online]. Available: https://sid.ir/paper/132737/en

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