Comprehensive Analysis of the Prognostic Marker and Immune Infiltrates of LDLR-Related Proteins Family Members in Breast Cancer

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Shahidi Shabnam; Ansari Shayesteh Parvin; Alami Mahsa; Parsamanesh Negin

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2024 | Volume:19 | Issue:1 Page(s): 31-49

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Title

Comprehensive Analysis of the Prognostic Marker and Immune Infiltrates of LDLR-Related Proteins Family Members in Breast Cancer

Author(s)

Shahidi Shabnam | Ansari Shayesteh Parvin | Alami Mahsa | Parsamanesh Negin | Issue Writer Certificate

Keywords

Breast cancerQ4

Immune InfiltrationQ4

LDLR-related proteinQ4

prognostic markerQ4

Abstract

Breast cancer is one of the common malignant tumors worldwide accounting for 15% of all cancer-related deaths. Since a timely diagnosis of BC is essential for optimal treatment and also increasing the survival rate of patients. Today, various financial support is applied to find the best biomarkers. Considering the financial issue, in-silico analysis is the best approach. LRP family proteins are important components of cell-surface receptors that involved in numerous biological activities. One of the most pivotal role LRPs is Wnt signaling pathway. Expression of LRP is related with BC malignancy. In this study, we first investigated expression of LRPs in BC tissues in comparison with normal tissues. Relation of LRP expression with RFS and OS. Then, we investigated the association of LRPs expression and immune infiltrating abundance.

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