Effective Ki-67 Reduction by Short-Term Administration of Letrozole Before Surgery in (Hormone-Positive) Breast Cancer

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Eslami Bita; Alipour Sadaf; Golfam Farzaneh; Jahabnin Behnaz; Omranipour Ramesh

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PATHOLOGY (IJP) Year:2024 | Volume:19 | Issue:1 Page(s): 103-106

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Title

Effective Ki-67 Reduction by Short-Term Administration of Letrozole Before Surgery in (Hormone-Positive) Breast Cancer

Author(s)

Keywords

Breast cancerQ4

Ki-67 AntigenQ4

LetrozoleQ4

PostmenopauseQ4

Abstract

Background & Objective: Antigen Ki-67 (histone-based nuclear protein) is a static marker of tumor cell proliferation and growth and is commonly measured to indicate the effect of treatment in Breast cancer patients. This single-arm trial study aimed to evaluate the effect of short-term endocrine therapy (letrozole) on Ki-67 levels in menopausal women with early hormone-positive Breast cancer who were referred to two university hospitals.Methods: Patients with a pre-treatment Ki67 of 5% or less were excluded from the study. Participants (n=25) received oral Letrozole (2.5 mg daily) seven days before surgery. Ki-67% on both the biopsy and the surgical specimens were measured and compared.Results and Conclusion: The mean age of patients was 62±9.4 (48-83 years). Our result indicated that consumption of Letrozole before surgery for hormone-positive Breast cancer can significantly decrease the level of Ki-67 (23.24±9.74 vs. 16.92±9.55, P=0.001 by paired t-test), with no drug-related adverse events.

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