Evaluation of the Relationship between T2*CMR and Cardiac Depolarization and Repolarization Parameters in Beta-Thalassemia Patients

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Ghandi Yazdan; Ghahremani Bita; Eghbali Aziz; Yousefichaijan Parsa; Bahrami Masoud

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Journal Paper

Paper Information

Journal: Journal of Kerman University of Medical Sciences Year:2024 | Volume:31 | Issue:1 Page(s): 46-50

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Title

Evaluation of the Relationship between T2*CMR and Cardiac Depolarization and Repolarization Parameters in Beta-Thalassemia Patients

Author(s)

Keywords

Beta-Thalassemia MajorQ4

DepolarizationQ4

ECGQ4

RepolarizationQ4

T2*CMRQ4

Abstract

Background: Cardiac iron overload causes severe cardiac complications and is a leading cause of death in Beta-Thalassemia Major patient. T2*CMR can detect preclinical cardiac iron overload. We evaluated the ability of 12-lead electrocardiographic atrial and ventricular Depolarization and Repolarization parameters to predict cardiac iron loading in TM.Materials and methods: This cross-sectional study was conducted on Patients with Beta thalassemia major; all participants underwent standard 12 lead electrocardiogram during a single study visit and the Depolarization and Repolarization parameters of ECG were measured and compared to the cardiac iron level detected by T2*CMR, with a detectable cardiac iron cutoff of T2*less than 20 ms.Results: A total of 26 patients (mean 26.19 years old, 34.62% male) were included. Mean T2*CMR values were 21.53 ms (46.15% <20 ms, 53.85% ≥20 ms). Among ECG parameters, only Pwd, QTc and QTcd (p: 0.026, 0.030, and 0.006 respectively) were significantly prolonged in patients with T2* < 20 ms compared to patients with T2*≥ 20 ms. There was a statistically negative Correlation between T2 * CMR and Pwd and QTcd (p: 0.028, and 0.021 respectively). Moreover, no correlation was found between Tp-e, Tp-e d, JTc, JTcd, Tp-e/QT, Tp-e/JT, Tp-e/JTc and T2* values.Conclusions: PWD and QTcd can be used as an alternative to T2*CMR to predict cardiac iron load levels in patients with beta thalassemia major.

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