CCR4 1014C/T and CCL22 16C/A Genetic Variations in Iranian Patients with Thyroid Cancer

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Dabbaghmanesh Mohammad Hossein; Rezaei Bahare; Haghshenas Mohammad Reza; Montazeri Najafabady Nima; Mohammadian Amiri Rajeeh; Erfani Nasrollah

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MIDDLE EAST JOURNAL OF CANCER Year:621 | Volume: | Issue: Page(s): 404-410

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

CCR4 1014C/T and CCL22 16C/A Genetic Variations in Iranian Patients with Thyroid Cancer

Author(s)

Keywords

CC chemokine receptor 4Q4

CCL22 chemokineQ4

Genetic variationsQ4

Single Nucleotide PolymorphismQ4

Thyroid cancerQ4

Cancer progressionQ4

Abstract

Background: The aim of this study was to investigate the association between Thyroid cancer and 16C/A Single Nucleotide Polymorphism (SNP) in C-C motif chemokine 22 (CCL22) as well as 1014C/T SNP in C-C chemokine receptor type 4 (CCR4).Method: In this case-control study, polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP) was performed for 113 Thyroid cancer patients and 112 age-sex matched healthy controls to investigate the genotype distribution.Results: At position 16C/A in CCL22, 95 patients (84.3%) were found to have CC genotype, while 17 individuals (14.8%) inherited CA genotype and 1 (0.9%) had AA genotype. In the control group, 92 volunteers (82.1%) inherited CC genotype, 18 individuals (16.1%) had CA genotype, and 2 (1.8%) had AA genotype. The frequency of CC, CT, and TT genotypes of 1014C/T SNP in CCR4 gene was 60 (53.1%), 43 (38.1%), and 10 (8.8%) in the patients, and 57 (53.3%), 43 (40.2%), and 7 (6.5%) in the control group, respectively. There were no statistically significant differences between the patients and controls in terms of 16C/A polymorphism in CCL22 (P = 0.816) and 1014C/T SNP in CCR4 1014C/T gene position (P = 0.801). Nevertheless, the study of their association indicated that inheriting the CC genotype of CCR4 was significantly associated with higher stages (stages 3 and 4) in Thyroid cancer.Conclusion: 1014C/T genetic variation in CCR4 and 16C/A polymorphism in CCL22 were not found to have a role in genetic susceptibility to Thyroid cancer. Inheriting CC genotype at 1014 locus in CCR4 may; however, affect Cancer progression in patients with Thyroid cancer.

Cites

No record.

References

No record.

Cite

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops