The Effect of 8 Weeks of Aerobic Training on Serum Levels of Asprosin and Insulin Resistance Index in Diabetic Rats

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Yousefinejad Mehrdad; Omidi Mahnaz; Taheri Kalani Abdol Hossein

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Journal Paper

Paper Information

Journal: Iranian Journal of Diabetes and Metabolism Year:2024 | Volume:24 | Issue:3 Page(s): 162-169

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Information Journal Paper

Title

The Effect of 8 Weeks of Aerobic Training on Serum Levels of Asprosin and Insulin Resistance Index in Diabetic Rats

Author(s)

Yousefinejad Mehrdad | Omidi Mahnaz | Taheri Kalani Abdol Hossein | Issue Writer Certificate

Keywords

Aerobic ExerciseQ4

Wistar RatQ4

Type 2 Diabetes MellitusQ4

Insulin ResistanceQ4

Asprosine HormoneQ4

Abstract

2Background: Diabetes is a global epidemic and the most common metabolic disorder caused by impaired insulin secretion and glucose metabolism. The aim of this study was to investigate the effect of 8 weeks of aerobic training on serum levels of asprosin and Insulin Resistance index in diabetic rats. Methods: The statistical population of this research included 40 10-week-old mice with an initial weight of 250 ± 20 grams, which were randomly divided into four groups (10 mice in each group): diabetic-exercise group (DT), diabetic group - Control (DC), healthy-training group (HT) and healthy-control group (HC) were divided. The program of Aerobic Exercises was performed for 8 weeks (5 sessions per week) in the form of running on a treadmill. Independent t-test and one-way analysis of variance (ANOVA) with Tukey's post hoc test were used to compare the groups. All data were analyzed at a significance level of 0.05 using SPSS-25 software. Results: The results of the present study showed that streptozotocin injection induced diabetes in mice (P= 0.001). Induction of diabetes caused a significant increase in the serum levels of asprosin and Insulin Resistance in mice (P= 0.048 and P= 0.012, respectively). Eight weeks of aerobic training decreased the serum levels of asprosin and decreased Insulin Resistance in diabetic rats (P= 0.001 and P= 0.036, respectively). Conclusion: Induced diabetes causes Insulin Resistance and increase in serum levels of asprosine, which can be improved by performing Aerobic Exercises.

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