The Effect of High Intensity Interval Training on Hepatic TCF7L2 Expression and Glycemic Control in Type 2 Diabetes Rats

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Parsayy rad Arash; Khorshidi Davood; kiani Fatemeh

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Journal Paper

Paper Information

Journal: Iranian Journal of Diabetes and Metabolism Year:2024 | Volume:24 | Issue:3 Page(s): 170-178

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Information Journal Paper

Title

The Effect of High Intensity Interval Training on Hepatic TCF7L2 Expression and Glycemic Control in Type 2 Diabetes Rats

Author(s)

Parsayy rad Arash | Khorshidi Davood | kiani Fatemeh | Issue Writer Certificate

Keywords

Interval TrainingQ4

Type 2 DiabetesQ4

GluconeogenesisQ4

TCF7L2Q4

Abstract

2Background: Transcription factor 7-like 2 (TCF7L2) is one of the strongest genetic risk factors associated with Type 2 Diabetes mellitus (T2DM). The purpose of this study was to investigate the effect of 10 weeks of high intensity Interval Training (HIIT) on hepatic TCF7L2 expression in T2DM rats. Methods: In this experimental study, fourteen males Wistar rats with T2DM induced by streptozotocin-nicotinamide injection were randomly divided into exercise (n=7) and control (n=7) groups. The exercise group performed the HIIT protocol on a treadmill for 10 weeks and 5 days per week. Hepatic TCF7L2 expression, blood glucose level, hemoglobin A1c (HbA1c), insulin and insulin resistance were measured 48 hours after the last training session. Data were analyzed by independent T test at P< 0.05. Results: Hepatic TCF7L2 expression and serum insulin were significantly higher in the exercise group compared to the control group (P˂0.05). Blood glucose level, HbA1c and insulin resistance were significantly lower in the exercise group than in the control group (P˂0.05). Conclusion: Based on these findings, it seems that the improved glycemic control in response to HIIT is partially dependent on the inhibition of Gluconeogenesis caused by increased hepatic TCF7L2 expression.

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