Changes in Trx-Sh/Trx-S2 Levels and Glutathione Values and Total Antioxidant Capacity Following 8 Weeks of High Intensity Interval Training with and Without Sodium Citrate Supplementation in Diabetic Rats

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Kashfi moghadam Malahat; Seifi skishahr Farnaz; Bolboli Lotfali

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Journal Paper

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Journal: Iranian Journal of Diabetes and Metabolism Year:2024 | Volume:24 | Issue:3 Page(s): 189-198

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Title

Changes in Trx-Sh/Trx-S2 Levels and Glutathione Values and Total Antioxidant Capacity Following 8 Weeks of High Intensity Interval Training with and Without Sodium Citrate Supplementation in Diabetic Rats

Author(s)

Kashfi moghadam Malahat | Seifi skishahr Farnaz | Bolboli Lotfali | Issue Writer Certificate

Keywords

Sodium CitrateQ4

Total AntioxidantQ4

GlutathioneQ4

ThioredoxinQ4

DiabetesQ4

Abstract

2Background: The present study aimed to investigate the changes in TRx-sh/TRx-s2 levels, GSH values, and Total Antioxidant capacity following 8 weeks of intense interval training with and without Sodium Citrate supplementation in diabetic rats. Methods: In this semi-experimental and fundamental study, 50 male Wistar rats were randomly divided into 5 groups: healthy control, control control, selective - exercise, consumption-Sodium Citrate supplementation, and drink-Sodium Citrate supplementation. The training protocol included 8 weeks of HIIT training with an intensity of 90% of the maximum speed. The supplement and exercise-supplement groups received daily (764 mg/kg) Sodium Citrate supplement in the form of a solution in water, three hours before the exercise. 72 hours after the last training session, blood sampling was done and the ELISA method analyzed research variables. To compare study groups, one-way analysis of variance and LSD post hoc test were used in SPSS software (P≥ 0.05). Results: The results showed that the levels of TRx-sh/TRx-s2, GSH, and TAC were significantly different among the five research groups (P= 0.001). Also, the results showed the levels of TRx-sh/TRx-s2, TAC, and GSH in the control-diabetic group (P= 0.001), diabetic-exercise (P= 0.001), and diabetic-supplement group (P= 0.001). and diabetic-supplement-exercise (P= 0.001) had a significant decrease compared to the healthy control group. The levels of TRx-sh/TRx-s2, GSH, and TAC in the diabetic-supplement and diabetic-supplement-exercise groups were significantly increased compared to the diabetic control group (P= 0.001). According to the difference in means, the increase of TRx-sh/TRx-s2, TAC, and GSH was higher in the diabetic-supplemented group. Conclusion: According to the results of the research, it can be assumed that training and Sodium Citrate supplementation are effective in improving Diabetes and this effect is probably exerted by increasing TRx-sh/TRx-s2, TAC, GSH.

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