Comparison of the Cure Rate in Blood Cancer Patients using Defective Marshall-olkin Extended Weibull Model

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Kadkhoda Dariush; Baghestani Ahmad Reza; Parkhideh Sayeh; Bonakchi Hossein; Khadem Maboudi Ali Akbar

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Red Crescent Medical Journal Year:2023 | Volume:25 | Issue:12 Page(s): 1-8

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Comparison of the Cure Rate in Blood Cancer Patients using Defective Marshall-olkin Extended Weibull Model

Author(s)

Keywords

cure rateQ4

Defective modelsQ4

Hematologic neoplasmsQ4

Survival AnalysisQ4

Abstract

Background: Blood cancer is a type of cancer that affects the blood cells derived from the bone marrow. Leukemia, lymphoma, and myeloma are the most common subtypes. Usually, bone marrow transplantation (BMT) is performed alongside curative treatments, such as chemotherapy and radiotherapy to transfuse healthy hematopoietic stem cells into a person after their own unhealthy bone marrow has been treated to kill invasive cells. Objectives: The aim of this study was to compare the percentage of remission (cure rate) between different types of blood cancer. Methods: In this retrospective cohort study, 458 patients who received BMT between 2007 and 2014 were analyzed. Patients were followed up until 2017 to determine whether they were still alive or had relapsed. The defective Marshall-Olkin Extended Weibull model was used with death being the event of interest. Results: The study included 34 cases of acute lymphoblastic leukemia, 155 cases of multiple myeloma, 59 cases of acute myeloid leukemia, 156 cases of Hodgkins lymphoma, and 54 cases of non-Hodgkin 's lymphoma. The cure rate was highest in patients with Hodgkin 's lymphoma and multiple myeloma, while it was lowest in patients with acute lymphoblastic leukemia. in addition, age had an inverse effect on the cure rate for blood cancer (P=0. 003), and relapse after BMT had a negative effect on the cure rate (P=0. 003). In addition, relapse before transplantation had no effect, and body mass index was found to influence cure rate. A sensitivity analysis showed that the estimated cure rates increased slightly with decreasing cohort length. Conclusion: Multiple myeloma and Hodgkin 's lymphoma had the highest cure rate, while acute lymphoblastic leukemia is barely curable. Obesity may increase the potential for cure and the experience of recurrence after BMT is associated with a lower cure rate.

Cites

No record.

References