Sex Differences on the Pharmacokinetics of Drugs for Children with Chronic Kidney Disease: A Narrative Review

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Faghihi Toktam; Assadi Farahnak

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Advanced Pharmaceutical Bulletin Year:2024 | Volume:14 | Issue:3 Page(s): 537-542

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Information Journal Paper

Title

Sex Differences on the Pharmacokinetics of Drugs for Children with Chronic Kidney Disease: A Narrative Review

Author(s)

Faghihi Toktam | Assadi Farahnak | Issue Writer Certificate

Keywords

Keywords: ChildrenQ4

Chronic kidney diseaseQ4

PharmacotherapyQ4

PharmacokineticsQ4

Sex differencesQ4

Abstract

Effective optimal Pharmacotherapy requires a comprehensive understanding of the drug’s pharmacokinetic properties. Chronic kidney disease (CKD) influences medication Pharmacokinetics. However, whether Sex differences exist in the Pharmacokinetics of drugs for children with CKD is unknown. The primary aim of this article was to evaluate the effect of sex on Pharmacokinetics of drugs commonly used for CKD treatment in children. Secondary outcome was to address the impact of sex in CKD disease progression. Electronic databases, PubMed, EMBASE, Google Scholar, and Web of Science were searched from inception, using Mesh terms in English for Sex differences in the Pharmacokinetics of drugs in children with CKD. No studies have documented sex-related differences in the Pharmacokinetics of drugs for the treatment of CKD in children. As a consequence, it is difficult to predict the effect of sex on Pharmacokinetics by extrapolating data from adult studies to children. Evidence to date suggests that girls generally have a higher prevalence and disease progression of CKD when compared to boys regardless of age. Understanding the Pharmacokinetics and pharmacodynamics of drugs provides practical consideration for dosing optimal medication regimens. Future kinetic studies are needed evaluating the effect of sex on the Pharmacokinetics and pharmacodynamics of drugs in children with CKD.

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