Novel Advances in Cell-Free Therapy for Premature Ovarian Failure (POF): A Comprehensive Review

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Yahyavi Yahya; Kheradi Niloufar; Karimi Abbas; Ebrahimi Kalan Abbas; Ramezani Fatemeh; Yousefi Soudabe; Teymouri Nobari Shirin; Sadrekarimi Hourieh; Nouri Mohammad; Edalati Mahdi

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Journal: Advanced Pharmaceutical Bulletin Year:2024 | Volume:14 | Issue:3 Page(s): 543-557

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Title

Novel Advances in Cell-Free Therapy for Premature Ovarian Failure (POF): A Comprehensive Review

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Keywords

PRPQ4

Exosome therapyQ4

In vitro activationQ4

Stem cell therapyQ4

Mitochondrial targeting therapiesQ4

Theca cells signaling pathwaysQ4

PLT-ExosQ4

Abstract

Premature ovarian failure (POF), is a condition characterized by the early decline of ovulation function. POF is a complex disorder that can be caused by various factors, and the idiopathic form represents a significant proportion of POF patients. Hormone replacement therapy (HRT) is currently considered the first-line treatment for POF. This review aims to provide a comprehensive overview of recent advancements in platelet-rich plasma (PRP), In vitro activation (IVA), Stem cell therapy, Exosome therapy, microRNAs, and Mitochondrial targeting therapies as a promising cell-free therapeutic approach in reproductive medicine. PLT-Exos, a new generation of cells, has been used to treat POF for more than a decade and has been shown to attenuate oocyte morphology and promote the differentiation of theca cells through the upregulation of PI3K/Akt and Bcl2, as well as the downregulation of the Smad and Bax signaling pathways. This review summarizes the current state of the art in the field of PLT-Exos and discusses the advantages and limitations of their potential clinical applications.

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