Delayed-Onset Endophthalmitis after Intravitreal Aflibercept Injection

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Akbarzadeh Ali; Rahimi Masoud; Zand Amin; Ghasemi Falavarjani Khalil

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Journal Paper

Paper Information

Journal: Journal of Current Ophthalmology Year:2023 | Volume:35 | Issue:2 Page(s): 195-198

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Information Journal Paper

Title

Delayed-Onset Endophthalmitis after Intravitreal Aflibercept Injection

Author(s)

Akbarzadeh Ali | Rahimi Masoud | Zand Amin | Ghasemi Falavarjani Khalil | Issue Writer Certificate

Keywords

Aflibercept

Anti-vascular endothelial growth factor

Chronic

Delayed onset

Infectious endophthalmitis

Intravitreal injection

Abstract

Purpose: To describe delayed-onset Infectious endophthalmitis 4 months after intravitreal Aflibercept injection. Methods: An 80-year-old female was referred with signs and symptoms of clinical endophthalmitis 4 months after Intravitreal injection of Aflibercept for choroidal neovascularization. Noninfectious causes of panuveitis were excluded and she was diagnosed with delayed-onset postinjection Infectious endophthalmitis. Vitreous and aqueous specimens were prepared and antibiotics (vancomycin and ceftazidime) were injected intravitreally. Results: Vitreous culture was positive for Staphylococcus epidermidis. During the 1st month after the antibiotic injections, symptoms and signs of the patient improved and became stable during the 6-month follow-ups. Conclusions: Delayed-onset Infectious endophthalmitis can be presented following Intravitreal injections. Late presentation of uveitis in postinjected eyes needs complete investigations to rule out Infectious endophthalmitis as an ophthalmic emergency.

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