The Impact of Vanadium-Zinc Supplementation Combined with Two Different Intensities of Aerobic Exercise on Modulation of Lipid Profile and Insulin Resistance in Rats Fed High-Fructose Corn Syrup

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Hamedchaman Nader; Safarzade Alireza; Hamidian Gholamreza; Nasiri Khadijeh

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Journal Paper

Paper Information

Journal: Journal of Military Medicine Year:2023 | Volume:25 | Issue:3 Page(s): 1880-1891

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Information Journal Paper

Title

The Impact of Vanadium-Zinc Supplementation Combined with Two Different Intensities of Aerobic Exercise on Modulation of Lipid Profile and Insulin Resistance in Rats Fed High-Fructose Corn Syrup

Author(s)

Hamedchaman Nader | Safarzade Alireza | Hamidian Gholamreza | Nasiri Khadijeh | Issue Writer Certificate

Keywords

AerobicQ4

TrainingQ4

VanadiumQ4

ZincQ4

Insulin ResistanceQ4

FructoseQ4

Abstract

Background and Aim: Insulin Resistance is a metabolic disorder marked by insufficient tissue response to insulin secretion and hyperinsulinemia. This metabolic abnormality plays a crucial role in the pathogenesis of many diseases. It appears that changes in lifestyle, such as participating in exercise activity and consumption of non-medicinal supplements, will ameliorate this condition; therefore, the present study aims to investigate the effects of Aerobic exercise and Vanadium-Zinc supplementation on body composition, lipid profile, and Insulin Resistance index in Fructose-fed rats. Methods: In this experimental study, 56 male wistar rats were randomly assigned to one of seven groups (eight rats per group); 1) Normal control (NC), 2) Fructose control (FC), 3) Fructose + Moderate-intensity continuous Training (FIT), 4) Fructose + High-intensity interval Training (FCT), 5) Vanadium-Zinc supplement (FS), 6) Moderate-intensity continuous Training + Vanadium-Zinc supplement (FSIT), and 7) High-intensity interval Training + Vanadium-Zinc supplement (FSCT). The protocol of moderate intensity continuous Training consisted of running for 12 to 54 min at a velocity of 12 to 20 m/min on a motorized treadmill with a 5% to 15% incline (weeks 1 to 8); also High-intensity interval Training performed 3 min bouts at 40 m/min, interspersed by 3 min active recovery at a running velocity of 20 m/min on a motorized treadmill with a 5% to 15% incline. Supplement groups received 10 mg/kg/day of Vanadium-Zinc through oral gavage. Body composition and serum levels of lipid profile, glucose, insulin, and HOMA-IR index were measured before and 48 hours after the final session of the Training program in a fast state. Results: Eight weeks of Aerobic exercise and Vanadium-Zinc supplementation significantly improved body composition (P=0.0001), Insulin Resistance (P=0.0001), and lipid profile indices (P≤0.05). Aerobic exercise combined with Vanadium-Zinc supplementation has the most significant impact on the modulation of serum Insulin Resistance, lipid profile, and, inguinal and retroperitoneal fat tissue (P≤0.05). Conclusion: Findings suggest that Vanadium-Zinc supplementation combined with Aerobic exercise can be effective in improving metabolic conditions and body composition.

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