The effects of eight weeks high intensity interval training on the levels of endothelial nitric oxide synthase (eNOS) gene expression in left ventricle of type 2 diabetic rats

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Noraie Fatemeh; Peeri Magsood; AZARBAYJANI MOHAMMAD ALI; DELFAN MARYAM

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Journal: Medical Journal of Tabriz University of Medical Sciences Year:2021 | Volume:43 | Issue:1 Page(s): 100-107

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Title

The effects of eight weeks high intensity interval training on the levels of endothelial nitric oxide synthase (eNOS) gene expression in left ventricle of type 2 diabetic rats

Author(s)

Noraie Fatemeh | Peeri Magsood | AZARBAYJANI MOHAMMAD ALI | DELFAN MARYAM | Issue Writer Certificate

Keywords

High Intensity Interval Training (HIIT)

Angiogenesis

Insulin Resistance

Abstract

Background: According to previous research’ s, the function of endothelial nitric oxide synthase (eNOS) impairs in diabetes. Therefore, the present study conducted aimed to investigate the effects of eight weeks high intensity interval training (HIIT) on the levels of eNOS gene expression in left ventricle tissue of type 2 diabetic rats. Methods: in experimental research, the 14 male Wistar rats with eight weeks old and the average weight of 160± 10 g feeding of high fat and sweet diets (30% fat and 25% fructose) for seven months. The rats after confirming the type 2 diabetes, randomly assigned into two groups of six rats consist of control and HIIT groups. The rats in the HIIT group trained for eight weeks and five sessions per week. The 24 hours after last training sessions, blood samples collected and the left ventricle removed and the levels of eNOS gene expression measured by Real Time PCR assay in heart tissue. Results: There was a significant increase in eNOS gene expression in HIIT group compared to the control group (p=0. 011). Moreover, the levels of glucose, insulin and Insulin Resistance (HOMA-IR) was significantly lower in the HIIT group compared to the control group (p<0. 05). Conclusion: It seems that HIIT play an important role in improving heart tissue endothelial function and improve the insulin sensitivity in diabetic rats by high fat and sweet diets.

Cites

References

High-intensity interval training (HIIT) effectively enhances heart function via miR-195 dependent cardiomyopathy reduction in high-fat high-fructose diet-induced diabetic rats

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APA: Copy

Noraie, Fatemeh, Peeri, Magsood, AZARBAYJANI, MOHAMMAD ALI, & DELFAN, MARYAM. (2021). The effects of eight weeks high intensity interval training on the levels of endothelial nitric oxide synthase (eNOS) gene expression in left ventricle of type 2 diabetic rats. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 43(1 ), 100-107. SID. https://sid.ir/paper/962597/en

Vancouver: Copy

Noraie Fatemeh, Peeri Magsood, AZARBAYJANI MOHAMMAD ALI, DELFAN MARYAM. The effects of eight weeks high intensity interval training on the levels of endothelial nitric oxide synthase (eNOS) gene expression in left ventricle of type 2 diabetic rats. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;43(1 ):100-107. Available from: https://sid.ir/paper/962597/en

IEEE: Copy

Fatemeh Noraie, Magsood Peeri, MOHAMMAD ALI AZARBAYJANI, and MARYAM DELFAN, “The effects of eight weeks high intensity interval training on the levels of endothelial nitric oxide synthase (eNOS) gene expression in left ventricle of type 2 diabetic rats,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 43, no. 1 , pp. 100–107, 2021, [Online]. Available: https://sid.ir/paper/962597/en

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