Reduction of Complements C3 and C4 in Saliva and Serum of Patients Suffering SARS-CoV-2 Infection

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Rahimi Petrudi Nima; Mirzaii Dizgah Iraj; Atashabparvar Ali; Hosseini Shokouh Seyyed Javad

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Journal Paper

Paper Information

Journal: Annals of Military and Health Sciences Research Year:2023 | Volume:21 | Issue:4 Page(s): 1-4

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Information Journal Paper

Title

Reduction of Complements C₃ and C₄ in Saliva and Serum of Patients Suffering SARS-CoV-2 Infection

Author(s)

Rahimi Petrudi Nima | Mirzaii Dizgah Iraj | Atashabparvar Ali | Hosseini Shokouh Seyyed Javad | Issue Writer Certificate

Keywords

Complement Proteins

Saliva

Serum

COVID-19

Abstract

Background: The complement system plays a role in chronic immune activation during viral infections. Objectives: This study aimed to evaluate the levels of Saliva and Serum complements C 3and C 4in coronavirus disease 2019 (COVID-19) patients and healthy individuals. Methods: This cross-sectional study included 36 severe and 22 critical COVID-19 hospitalized patients and 22 healthy individuals. Serum and unstimulated Salivary C 3and C 4levels were assessed using the immunoturbidimetric method and analyzed using one-way analysis of variance (ANOVA) with the Student-Newman-Keuls test as a post hoc analysis. Results: Salivary C 3and C 4levels were significantly lower in patients with severe and critical COVID-19 than in healthy individuals. There was no significant difference between the groups infected with severe and critical COVID-19. Serum C 3and C 4levels were lower in critical COVID-19 patients than in healthy individuals,nevertheless, no significant difference was observed between severe COVID-19 patients and healthy individuals. Additionally, Serum C 4levels were lower in critical COVID-19 patients than in severe COVID-19 patients. Conclusions: It appears that Serum and Salivary C 3and C 4levels decrease in patients with COVID-19 infection.

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