TAXANES BASED REGIMEN AS A RISK FACTOR FOR CHEMOTHERAPY INDUCED AMENORRHEA (CIA)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NAJAFI SAFA; ESMAEELI DJAVID GHOLAMREZA; MEHRDAD NEDA; RAJAII ELAHE; ALAVI NASRINSADAT; OLFATBAKHSH ASEIH; NAJAFI MASOMEH; BAHRAMI ALIREZA; HEIDARI KAZEM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Breast Diseases Year:2009 | Volume:2 | Issue:2 (5) Page(s): 7-13

Download Full-Text

Persian Verion

View:

2,482

Download:

Cites:

Information Journal Paper

Title

TAXANES BASED REGIMEN AS A RISK FACTOR FOR CHEMOTHERAPY INDUCED AMENORRHEA (CIA)

Author(s)

Keywords

CHEMOTHERAPYINDUCED AMENORRHEAQ4

TAXANESQ4

BREAST CANCERQ2

Abstract

Purpose: The objective of our study was so to show the impact of different chemotherapy regimens on induction of amenorrhea (CIA) in premenopausal women with BREAST CANCER at different 1 ages.Method: This is a follow-up study in 226 premenopausal women with BREAST CANCER, who received one of the three groups of chemotherapy regimens: Conventional (CMF), antracyclinebased, and anthracycline- TAXANES based. They were evaluated for incidence of CIA in the follow-up clinic of ICBC Iranain Center for Braest Cancer (ICBC). Statistical analysis using SPSS software was performed and logistic regression was used to determine the risk factors of CIA.Results: From 226 patients with a median age of 40 yrs (26-56 yrs) who participated in this study, 154 patients (68.1%) were developed CIA, which in 101 patients (65.6%), CIA was established and never resumed. CIA was present in 52.5% of patients treated with conventional regimens (CMF), in 66.7% of patients treated with anthracyclines and in 78.7% of patients treated with anthracycline-taxan. So the frequency of CIA was significantly higher in TAXANES based chemotherapy group than the others (p=0.015).Although a slightly superior incidence of CIA in patients with hormone-insensitive tumors (ER-and PR-) versus hormone-sensitive tumors (ER+/or PR+) treated with combination regimens was observed, no statistically significant difference was found (p=0.629). From all the risk factors that were evaluated, anthracycline-taxan based regimen (OR: 4.14.059, CI95%: 1.6 10.21.6-9.8) and age> 40 yrs (OR: 3.23.5, CI95%: 1.7-6.11.9-6.6) were the most important factors in developing CIA in the study.Conclusion: The type of chemotherapy and age at the BREAST CANCER diagnosis are the most important risk factors in CIA and TAXANES-based regimens induced more CIA than the other regimens.

Cites

No record.

References

No record.

Cite

APA: Copy

NAJAFI, SAFA, ESMAEELI DJAVID, GHOLAMREZA, MEHRDAD, NEDA, RAJAII, ELAHE, ALAVI, NASRINSADAT, OLFATBAKHSH, ASEIH, NAJAFI, MASOMEH, BAHRAMI, ALIREZA, & HEIDARI, KAZEM. (2009). TAXANES BASED REGIMEN AS A RISK FACTOR FOR CHEMOTHERAPY INDUCED AMENORRHEA (CIA). IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, 2(2 (5)), 7-13. SID. https://sid.ir/paper/144666/en

Vancouver: Copy

NAJAFI SAFA, ESMAEELI DJAVID GHOLAMREZA, MEHRDAD NEDA, RAJAII ELAHE, ALAVI NASRINSADAT, OLFATBAKHSH ASEIH, NAJAFI MASOMEH, BAHRAMI ALIREZA, HEIDARI KAZEM. TAXANES BASED REGIMEN AS A RISK FACTOR FOR CHEMOTHERAPY INDUCED AMENORRHEA (CIA). IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE[Internet]. 2009;2(2 (5)):7-13. Available from: https://sid.ir/paper/144666/en

IEEE: Copy

SAFA NAJAFI, GHOLAMREZA ESMAEELI DJAVID, NEDA MEHRDAD, ELAHE RAJAII, NASRINSADAT ALAVI, ASEIH OLFATBAKHSH, MASOMEH NAJAFI, ALIREZA BAHRAMI, and KAZEM HEIDARI, “TAXANES BASED REGIMEN AS A RISK FACTOR FOR CHEMOTHERAPY INDUCED AMENORRHEA (CIA),” IRANIAN QUARTERLY JOURNAL OF BREAST DISEASE, vol. 2, no. 2 (5), pp. 7–13, 2009, [Online]. Available: https://sid.ir/paper/144666/en

Related Journal Papers