INCIDENCE OF CHEMOTHERAPY-INDUCED AMENORRHEA IN NON-MENOPAUSAL WOMEN WITH BREAST CANCER

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KEYHANIAN SH.; FOTOUKIAN Z.; GHAFARI FATEMEH; VAHDANI M.; SHIRINKAM F.; SARAVI M.M.

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Journal: Journal of Mazandaran University of Medical Sciences Year:2009 | Volume:19 | Issue:70 Page(s): 9-17

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Title

INCIDENCE OF CHEMOTHERAPY-INDUCED AMENORRHEA IN NON-MENOPAUSAL WOMEN WITH BREAST CANCER

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Keywords

BREAST CANCERQ3

AMENORRHEAQ2

CHEMOTHERAPYQ2

ON-MENOPAUSAL WOMENQ3

Abstract

Background and purpose: Although adjunct CHEMOTHERAPY may increase life in non-menopausal BREAST CANCER patients, however, it may cause short-term complications such as nausea, vomiting, alopecia, as well as long-term complications in ovarian failure and premature menopausal. The objective of this study was to investigate CHEMOTHERAPY-induced secondary AMENORRHEA in non-menopausal women with BREAST CANCER.Materials and methods: A descriptive design (case series) was preformed on fifty BREAST CANCER patients, non-menopausal (normal mense) and CHEMOTHERAPY in Ramsar Emam Sajad Hospital Oncology unit from 2007 to 2008. Sampling was consecutive. Data gathering method was questionnaire & blood sampling (FSH & Progesterone) for prior and 12 months after the end of CHEMOTHERAPY. Data was analyzed by paired-t, independent-t and one-way ANOVA tests.Results: Results showed that 62% of patients were AMENORRHEA 12 months after the end of CHEMOTHERAPY. Results showed that there was no meaningful relationship between age, hormone therapy, disease stage, node-positive and ER & PR status to AMENORRHEA; however, there was a meaningful relationship between duration of treatment, type and dose of CHEMOTHERAPY to AMENORRHEA.Conclusion: In pre-menopausal patients with BREAST CANCER, receiving cytotoxic CHEMOTHERAPY against tumor cells, AMENORRHEA may occur do to ovarian failure.

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APA: Copy

KEYHANIAN, SH., FOTOUKIAN, Z., GHAFARI, FATEMEH, VAHDANI, M., SHIRINKAM, F., & SARAVI, M.M.. (2009). INCIDENCE OF CHEMOTHERAPY-INDUCED AMENORRHEA IN NON-MENOPAUSAL WOMEN WITH BREAST CANCER. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 19(70), 9-17. SID. https://sid.ir/paper/44930/en

Vancouver: Copy

KEYHANIAN SH., FOTOUKIAN Z., GHAFARI FATEMEH, VAHDANI M., SHIRINKAM F., SARAVI M.M.. INCIDENCE OF CHEMOTHERAPY-INDUCED AMENORRHEA IN NON-MENOPAUSAL WOMEN WITH BREAST CANCER. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;19(70):9-17. Available from: https://sid.ir/paper/44930/en

IEEE: Copy

SH. KEYHANIAN, Z. FOTOUKIAN, FATEMEH GHAFARI, M. VAHDANI, F. SHIRINKAM, and M.M. SARAVI, “INCIDENCE OF CHEMOTHERAPY-INDUCED AMENORRHEA IN NON-MENOPAUSAL WOMEN WITH BREAST CANCER,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 70, pp. 9–17, 2009, [Online]. Available: https://sid.ir/paper/44930/en

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