Apoptosis as a Potential Target to Arrest and Survival of Hydatid Cyst

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Rahmani Dehaghani Maryam; Tolouei Sepideh; Yousofi Darani Hossain; Ghayour Najafabadi Zahra

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Journal Paper

Paper Information

Journal: Advanced Biomedical Research Year:2023 | Volume:12 | Issue:june Page(s): 1-8

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Title

Apoptosis as a Potential Target to Arrest and Survival of Hydatid Cyst

Author(s)

Rahmani Dehaghani Maryam | Tolouei Sepideh | Yousofi Darani Hossain | Ghayour Najafabadi Zahra | Issue Writer Certificate

Keywords

ApoptosisQ4

BaxQ4

Bcl-2Q4

Caspase 3Q4

Fas-LQ4

hydatid cystQ4

Abstract

Background: Hydatidosis is a serious and life-threatening disease that may lead to the death of the host if diagnosed and treated improperly. Apoptosis has been investigated as a mechanism of host innate immunity in suppressing parasites and also the survival of cysts in the human body. The present study investigates the process and role of Apoptosis caused by a host cell or parasite in hydatid cysts. Materials and Methods: Survey cytotoxic effect and apoptotic mortality of hydatid-treated lymphocytes were investigated. Also, to determine the mechanism of Apoptosis in host and parasite, the mean gene expressions of Bcl-2, Bax, Caspase 3 in hydatid-treated lymphocytes, and Fas-L gene in the laminated-germinal layer of fertile and infertile hydatid cysts were evaluated. Results: The viability of fertile and infertile hydatid fluid-treated lymphocytes was significantly different compared with the control group. Flow cytometry also showed apoptotic cells. Bax mean gene expression was significantly different between fertile and infertile treated lymphocytes. However, there was no significant difference in the mean expression of Caspase 3, and Bcl-2 genes in these two groups. Although the expression of the Fas-L gene in infertile cysts was higher than in fertile cysts, the result was not significant. Conclusion: It seems that hydatid cyst fluid may induce Apoptosis in lymphocytes so that, hydatid cysts can escape from the immune system and stay alive. On the other hand, the results represent the possible immune path of host Apoptosis against the parasite as one of the important routes in infertility of hydatid cysts.

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