Sequential changes in expression of long non-coding RNAs THRIL and MALAT1 after ischemic stroke

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Bayat Mahnaz; Hooshmandi Etrat; Karimi Najmeh; Rahimi Moosa; Tabrizi Reza; Asadabadi Tahereh; Salehi Mohammad Saied; Zafarmand Seyedeh Shaghayegh; Owjfard Maryam; Garcia Esperon Carlos; Spratt Neil; Levi Christopher; Borhani Haghighi Afshin

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Journal: Current Journal of Neurology Year:2024 | Volume:23 | Issue:1 Page(s): 74-82

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Title

Sequential changes in expression of long non-coding RNAs THRIL and MALAT1 after ischemic stroke

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Keywords

Long Noncoding RNA

MALAT1 Long Noncoding RNA

THRIL Long Noncoding RNA

Ischemic Stroke

Abstract

Background: Inflammation is the major contributor to the pathophysiology of Ischemic Stroke (IS). Long non-coding ribonucleic acids (lncRNAs) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and tumor necrosis factor and heterogeneous nuclear ribonucleoprotein L-related immunoregulatory (THRIL) have been demonstrated to be up-regulated in inflammation and atherosclerosis. Therefore, we aimed to study the expression profile of these lncRNAs after IS.Methods: This observational case-control study was conducted in Namazi Hospital, Shiraz, Iran. The real-time polymerase chain reaction (RT-PCR) measured the sequential changes in circulating levels of MALAT1 and THRIL on days 1, 3, and 5 after IS. The receiver operating characteristic (ROC) curve analysis was used to estimate the diagnostic and prognostic potential of lncRNAs with the area under the curve (AUC).Results: In patients with IS, the relative MALAT1 and THRIL expressions were significantly higher than the controls (P < 0.001 and P < 0.01, respectively), on days 1, 3, and 5 after stroke. We showed a significantly increase in lncRNAs expression on day five compared to days 1 and 3 after stroke. Moreover, a positive correlation was detected between MALAT1 expression and time within the first 24 hours after stroke (r = 0.27, P = 0.03). Logistic regression analysis showed a significant positive association between MALAT1 and THRIL and the risk of stroke evolution. We found a potential diagnostic marker for MALAT1 with an AUC of 0.78.Conclusion: We demonstrated the significant sequential upregulation in MALAT1 and THRIL expression on days 1, 3, and 5 after IS with a significant positive association with the risk of stroke. MALAT1 also significantly correlated with time within the first 24 hours after stroke.

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