Gene expression in luminal A breast cancer and its correlation with chemoradiotherapy outcome and recurrence

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Ma J.; Gan T.; Song A.

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Journal Paper

Paper Information

Journal: International Journal of Radiation Research Year:2024 | Volume:22 | Issue:2 Page(s): 251-256

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Title

Gene expression in luminal A breast cancer and its correlation with chemoradiotherapy outcome and recurrence

Author(s)

Ma J. | Gan T. | Song A. | Issue Writer Certificate

Keywords

Breast neoplasms

luminal a subtype

gene expression

clinical efficacy

recurrence

Abstract

Background: Breast cancer is a common cancer that affects women. The luminal a subtype of breast cancer is defined by low Ki67 expression (<14%), Her-2 negative, and positive ER and PR. Luminal A exhibits a favorable prognosis compared to other breast cancer types. Materials and Methods: gene expression profiling was employed in this investigation to discover genes linked to clinical efficacy and recurrence in Luminal A breast cancer tissue samples. The study's overarching goal was to discover new therapeutic targets by deciphering the molecular mechanisms behind Luminal A breast cancer. Results: Our analysis revealed specific genes linked to Luminal A breast cancer, and their expression levels were correlated with clinical outcomes. High expression of certain genes was associated with improved clinical efficacy and a reduced recurrence rate. Conclusion: The study provides valuable insights into the molecular mechanisms of Luminal A breast cancer, offering potential targets for personalized therapeutic approaches.

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