STUDY ON ANTI-CANCER EFFECT OF PLANT EXTRACT ACA-1 ON GASTRIC ADENOCARCINOMA CELL LINE

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GHAZANFARI T.; ZAMANI TAGHIZADEH RABE SH.; YARAEE R.; MAHMOUDI M.

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Journal: Journal of Medicinal Plants Year:2012 | Volume:11 | Issue:42 Page(s): 154-162

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Title

STUDY ON ANTI-CANCER EFFECT OF PLANT EXTRACT ACA-1 ON GASTRIC ADENOCARCINOMA CELL LINE

Author(s)

GHAZANFARI T. | ZAMANI TAGHIZADEH RABE SH. | YARAEE R. | MAHMOUDI M. | Issue Writer Certificate

Keywords

CANCERQ2

ACA-1Q2

APOPTOSISQ1

CASPASEQ2

Abstract

Background: APOPTOSIS provides solutions for the treatment of CANCERs and its induction is used as a strategy for preparing drugs that destroy pre-neoplastic cells. Many plant compounds have anti-tumoral activity. ACA-1 plant product is an aqueous extract and has been used in traditional medicine in Iran and has cytotoxicity effect on melanoma CANCER cells.Objective: In this study, anti-CANCER effect of ACA-1 plant product on gastric adenocarcinoma cells was evaluated and the mechanism of its action was studied.Methods: Cytotoxicity of ACA-1 on gastric adenocarcinoma cells (AGS) and fibroblasts (HgF) was determined after 24 hours of incubation by MTT assay. Annexin V-FITC and PI staining method was used for measuring the cell APOPTOSIS. Activity of CASPASE 8 and 9 was assayed by enzymatic method. An ECMatrix was used for determining invasion ability of AGS cells.Results: ACA-1 showed strong and dose - dependent toxicity on AGS cells by induction of early APOPTOSIS. Increase in CASPASE 8 and 9 activities was involved in this process. Also, ACA-1 decreases the invasion ability on AGS cells.Conclusion: ACA-1 induced APOPTOSIS in human gastric CANCER cells by activating CASPASE 8 and 9. With respect to decreasing cell invasion of AGS cells, ACA-1 may be considered as a potential candidate against human gastric CANCER.

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APA: Copy

GHAZANFARI, T., ZAMANI TAGHIZADEH RABE, SH., YARAEE, R., & MAHMOUDI, M.. (2012). STUDY ON ANTI-CANCER EFFECT OF PLANT EXTRACT ACA-1 ON GASTRIC ADENOCARCINOMA CELL LINE. JOURNAL OF MEDICINAL PLANTS, 11(42), 154-162. SID. https://sid.ir/paper/15296/en

Vancouver: Copy

GHAZANFARI T., ZAMANI TAGHIZADEH RABE SH., YARAEE R., MAHMOUDI M.. STUDY ON ANTI-CANCER EFFECT OF PLANT EXTRACT ACA-1 ON GASTRIC ADENOCARCINOMA CELL LINE. JOURNAL OF MEDICINAL PLANTS[Internet]. 2012;11(42):154-162. Available from: https://sid.ir/paper/15296/en

IEEE: Copy

T. GHAZANFARI, SH. ZAMANI TAGHIZADEH RABE, R. YARAEE, and M. MAHMOUDI, “STUDY ON ANTI-CANCER EFFECT OF PLANT EXTRACT ACA-1 ON GASTRIC ADENOCARCINOMA CELL LINE,” JOURNAL OF MEDICINAL PLANTS, vol. 11, no. 42, pp. 154–162, 2012, [Online]. Available: https://sid.ir/paper/15296/en

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