STUDY OF SEDATIVE AND ANXIOLYTIC EFFECT OF HERBAL EXTRACT OF NARDOSTACHYS JATAMANSI IN COMPARISON WITH DIAZEPAM IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

REZAEI ALI; PASHAZADEH M.; AHMADIZADEH CH.; JAFARI BEHBOUD; JALILZADEH HEDAYATI M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Medicinal Plants Year:2010 | Volume:9 | Issue:36 Page(s): 169-174

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

2,629

Download:

Cites:

Information Journal Paper

Title

STUDY OF SEDATIVE AND ANXIOLYTIC EFFECT OF HERBAL EXTRACT OF NARDOSTACHYS JATAMANSI IN COMPARISON WITH DIAZEPAM IN RATS

Author(s)

Keywords

NARDOSTACHYS JATAMANSIQ3

KETAMINQ2

DIAZEPAMQ3

ELEVATED PLUS MAZEQ3

Abstract

Background: Due to sedation, anticonvulsant and anti-pain effects, NARDOSTACHYS JATAMANSI has had a special place in traditional medicine of China, India and Iran. Regarding Alkaloid, Organic acid esters, valeric acid and isovalerates this plant has always been used to reduce nervous pressure and the treatment depression and chronic insomnia.Objective: Considering the importance of sedative and anxiolytic effects of this plant's we decided to have a comparative study of this plant with chemical drugs.Methods: In this study, first, the rhizome of N. jatamansi was extracted by hydromethanolic (70%) solvent and then, the presence of valporoates, in total extract was revealed by GC-MS analysis of its n-Hexane fraction. For studying the effectiveness of sedative and anxiolytic of N. jatamansi in compraison with DIAZEPAM different groups of female wistar rats received N. jatamansi (100, 200, 400 mg/kg, ip), DIAZEPAM (1.2 mg/kg, ip), di-metyl; solphoxid (DMSO) with equal volume, and 15 min after assessing the relif/sleep inducing effect (induced sleep duration by KETAMINe, 40 mg/kg, ip) and anxiolytic effects (using Elevated plus were done).Results: The GC-MS analysis of the n-hexan fraction of extract led to identification and quantification of fifteen compounds, the main components were a - Aristolen-1-alpha-ol (31.1%), valerenal (31%) and valerenic acid (26.5%). Pharmacological results showed that herbal extract of N. jatamansi with the maximum inhibition was observed at the does of 200 mg/kg of sedative and anxiolytic effect. Conclusion: Obtained resultes indicated that extract of N. jatamansi gives sedative and anxiolytic effects.

Cites

References

STANDARDIZATION OF THE SOUR ORANGE FLOWER AND LEAF

Cite

APA: Copy

REZAEI, ALI, PASHAZADEH, M., AHMADIZADEH, CH., JAFARI, BEHBOUD, & JALILZADEH HEDAYATI, M.. (2010). STUDY OF SEDATIVE AND ANXIOLYTIC EFFECT OF HERBAL EXTRACT OF NARDOSTACHYS JATAMANSI IN COMPARISON WITH DIAZEPAM IN RATS. JOURNAL OF MEDICINAL PLANTS, 9(36), 169-174. SID. https://sid.ir/paper/15328/en

Vancouver: Copy

REZAEI ALI, PASHAZADEH M., AHMADIZADEH CH., JAFARI BEHBOUD, JALILZADEH HEDAYATI M.. STUDY OF SEDATIVE AND ANXIOLYTIC EFFECT OF HERBAL EXTRACT OF NARDOSTACHYS JATAMANSI IN COMPARISON WITH DIAZEPAM IN RATS. JOURNAL OF MEDICINAL PLANTS[Internet]. 2010;9(36):169-174. Available from: https://sid.ir/paper/15328/en

IEEE: Copy

ALI REZAEI, M. PASHAZADEH, CH. AHMADIZADEH, BEHBOUD JAFARI, and M. JALILZADEH HEDAYATI, “STUDY OF SEDATIVE AND ANXIOLYTIC EFFECT OF HERBAL EXTRACT OF NARDOSTACHYS JATAMANSI IN COMPARISON WITH DIAZEPAM IN RATS,” JOURNAL OF MEDICINAL PLANTS, vol. 9, no. 36, pp. 169–174, 2010, [Online]. Available: https://sid.ir/paper/15328/en

Related Journal Papers