Effect of the Adiantum capillus-veneris Extract on Immunohistochemical Expression of Lung Heat-Shock Proteins in Rats Exposed to Hypoxia

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YADEGARI M.; MIRDAR SH.; HAMIDIAN GH.R.; BERENJEIAN TABRIZI H.

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Journal: Journal of Medicinal Plants Year:2019 | Volume:18 | Issue:72 Page(s): 183-191

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Title

Effect of the Adiantum capillus-veneris Extract on Immunohistochemical Expression of Lung Heat-Shock Proteins in Rats Exposed to Hypoxia

Author(s)

YADEGARI M. | MIRDAR SH. | HAMIDIAN GH.R. | BERENJEIAN TABRIZI H. | Issue Writer Certificate

Keywords

Adiantum capillus-venerisQ1

Heat shock proteinQ1

HypoxiaQ1

LungQ1

Abstract

Background: Despite the traditional use of the Adiantum capillus-veneris plant, there is little evidence of its clinical effects. Objective: The purpose of the present study was to investigate the effect of the Adiantum capillus-veneris extract on Immunohistochemical expression of Lung heat-Shock Proteins in rats exposed to Hypoxia. Methods: Twenty-four male Wistar rats (control: 8, training-Hypoxia: 8, training-Hypoxiasupplement: 8) without clinically evident disease were used. The rats were exposed to Hypoxia environment for 3 week following 6 weeks interval training. Tweleve of the experimental samples were taken 500 ml Adiantum capillus-veneris extract per body weight (kg) in during exposure to Hypoxia environment. Finally Lung tissue was removed for immunohistochemistry tests of HSP70 and HSP90. To analyze of data, ANOVA test was used (α ≤ 0. 05). Results: Expression of HSP70 and HSP90 increased significantly in Hypoxia group comparison with the control group (P≤ 0. 05). Expression of HSP70 and HSP90 protein decreased significantly in the Supplement Hypoxia group comparison with the Hypoxia group (P≤ 0. 05). Conclusion: Reduction effects of Adiantum capillus-veneris extract on expression of the parenchyma Lung heat-shock protein in Hypoxia conditions was observed that probably indicate decreased oxidative stress in the Lung.

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تاثیر عصاره پرسیاوش در تعدیل شاخص های آپوپتوزی Bax و Bcl2 ریوی رت های تمرین کرده و قرار گرفته در معرض تنش هایپوکسی

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APA: Copy

YADEGARI, M., MIRDAR, SH., HAMIDIAN, GH.R., & BERENJEIAN TABRIZI, H.. (2019). Effect of the Adiantum capillus-veneris Extract on Immunohistochemical Expression of Lung Heat-Shock Proteins in Rats Exposed to Hypoxia. JOURNAL OF MEDICINAL PLANTS, 18(72 ), 183-191. SID. https://sid.ir/paper/15367/en

Vancouver: Copy

YADEGARI M., MIRDAR SH., HAMIDIAN GH.R., BERENJEIAN TABRIZI H.. Effect of the Adiantum capillus-veneris Extract on Immunohistochemical Expression of Lung Heat-Shock Proteins in Rats Exposed to Hypoxia. JOURNAL OF MEDICINAL PLANTS[Internet]. 2019;18(72 ):183-191. Available from: https://sid.ir/paper/15367/en

IEEE: Copy

M. YADEGARI, SH. MIRDAR, GH.R. HAMIDIAN, and H. BERENJEIAN TABRIZI, “Effect of the Adiantum capillus-veneris Extract on Immunohistochemical Expression of Lung Heat-Shock Proteins in Rats Exposed to Hypoxia,” JOURNAL OF MEDICINAL PLANTS, vol. 18, no. 72 , pp. 183–191, 2019, [Online]. Available: https://sid.ir/paper/15367/en

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