Journal of Medicinal Plants
Year:2019 | Volume:18 | Issue:72 |Papers Count:28

Tribulus terrestris is a one-year-old herb dispersed in hot and humid areas in the Mediterranean and warm regions of Europe, Asia, Africa and Australia. This plant has many benefits and is used in traditional medicine for the treatment of various diseases, including kidney stones, low blood pressure, anti-diabetic properties, and treatment of cardiovascular diseases, gastrointestinal disorders, and sexual performance in men and in treatment of hepatitis is recommended. The aim of this study was to investigate the pharmacological and therapeutic properties of pharynx in traditional medicine and scientific papers in modern medicine. This study is a systematic review based on the PRISMA checklist. Based on keywords, 440 titles were selected and after removing repetitive articles, 129 papers were extracted from various databases including PubMed, SID, ScienceDirect, Scopus and Magiran, and the Google Scholar search engine without time limit. T. terrestris has several properties, including antimicrobial, antibacterial, free radicals purification and inhibition of lipid peroxidation, and through various mechanisms of cell and molecules, it produces various pharmacological and therapeutic properties. One of the most important therapeutic properties of this plant is its antiinflammatory and anti-cancer properties. Also, several clinical studies have shown that coadministration of tetanus extract with chemotherapy drugs reduces the side effects of drugs. Due to the lack of toxicity and side effects of T. terrestris, the use of herbs has been considered as a complementary drug in diet regimens for various diseases.

The use of herbal medicines dates back to the beginning of the human history. Today, herbal medicines still play a significant role in the prevention and treatment of disease in many cultures and communities. There are few reports about adverse effects of herbal medicines. This is why many people around the world believe that herbal medicines can't cause adverse effects. They believe plants are safe, even if they're not efficient. This idea is wrong, regardless of how common it might be considered. Plants can be dangerous and even lethal in some cases. It is not just plant chemicals that might cause adverse effects. The role of environmental pollutants and the presence of fraud in form of alternation and adulteration in herbal preparations is another factor that might contribute to harmful effects on various organs of the body, including the kidneys. Kidneys are vital organs that filter blood, remove wastes and excrete the wastes in the urine. They are susceptible to injury because of their high exposure to different chemical substances including chemicals from the herbs. This is why studying the possible adverse effects of herbal medicines on kidney structure and function gets important. This issue highlights the role of regulatory and legislator organizations in providing up-to-date laws to help maintain a better regulation on the production and consumption of herbal products. This article reviews the findings on this case. We used papers published between 1990 and January 2018 in pubmed and google scholar databases.

In recent years due to the demonstration of destructive side effects of chemical drugs, utilizing herbal drugs to treat diseases have increased. The medicinal Vaccinium is one of the popular plants which have many pharmaceutical, food and industrial values. There are about 100 species of this genus around the world but Ghare-Ghat (Vaccinium arctostaphlyus) is the only species present in Iran which has been reported in six regions of the country. The major metabolites in the leaves and fruits of Ghare-Ghat are phenols, especially anthocyanins, which have antioxidant properties. The fruit essence contains 30% sugar, 5. 15% protein, 1. 5% fat and the young shoots contain hexadecanoic acid, vitispirane Beta-ionone and sandaracopimaradiene. In Iranian traditional medicine, fruit infusion has been used to reduce blood sugar and blood pressure. Due to high levels of acid in Ghare-Ghat it has antibacterial effects and is used to treat bladder infections. It also has anti cyanosed compounds which help in the formation of stronger capillaries and reduction of the stickiness of blood platelets. Today, with the remarkable advances of biotechnology including tissue culture, access to high quality and quantity of products of this genus has increased. The genus Vaccinium and in particular Ghare-Ghat has high economic value in Iran and requires further study to increase its cultivation and production of food and pharmaceutical products.

Background: Increased Gastric residual volume (GRV) is one of the common problems in ICU. Objective: The aim of this study was to determine the effect of cumin extract on gastric residual volume in patients with traumatic episodes hospitalized in ICU. Method: This double-blind randomized clinical trial was conducted on 60 patients traumatic hospitalized in ICU. Patients were randomly assigned to one of two groups: cumin (n = 30) and distilled water (n = 30). In the intervention group, 6 grams of cumin extract in 3 divided doses were given 50 drops in 30 cc of urban water at 3 times every 8 hours after. The remaining volume was recorded for up to 4 consecutive days and the data were compared in two groups. (IRCT: 201610297494N24). Results: Before the intervention, there was no significant difference between the mean GRV in the cumin group and placebo group (P = 0. 63). Comparing the two groups of placebo and placebo, there was no significant difference in the amount of residual stomach in hospitalized patients with ICU on the first day (P = 0. 13), but on the second, third and fourth days, this difference was significant between the two groups (p = 0. 001). Comparing the two groups of intervention and placebo, the average volume of residual stomach before and during 4 consecutive days after intervention was significant (P = 0. 001). Conclusion: The results of this study showed that cumin extract was effective in decreasing residual stomach volume in hospitalized patients with ICU in comparison with placebo.

Background: Nitrogen is the most important nutrient requirement for plants. Nitrogen supplying affected the leaf area, carbon fixation, glandular trichomes formation, ATP and NADPH content which resulted to the terpenoids biosynthesis enhancement and essential oils accumulation. Objective: This study was aimed to evaluate changes of essential oil content and components by use different levels of Urea fertilizer and its relation with the antioxidant status of peppermint. Method: The two field experiments were conducted on randomized complete block design at 2013 and 2014. The treatments consisted of three levels of nitrogen fertilizer (urea) (0, 75, and 150 kg ha-1). The evaluated traits were included antioxidant enzymes, essential oil percentage and essential oil components. Results: The urea fertilizer had a significant effect (P≤ 0. 01) on the soluble protein amount and antioxidant enzymes activity. Urea consumption in the both years increased the peppermint essential oil content. The interaction of nitrogen fertilizer and year had a significant effect on most of the essential oil components excepted to β-pinene, myrcene, Limonene, 1, 8-Cineole, Z-β-Ocimene, and α-Terpineol. Conclusion: Using nitrogen fertilizer increased the peppermint essential oil content. Also, nitrogen deficiency reduced the soluble proteins and essential oil content and in contrast, it increased antioxidant enzymes activity and pulegone content. Therefore, consumption of 75 kg urea per hectare is recommended due to increasing essential oil content, decreasing pulegone rate, and no significant effect on menthol, menthone, and menthofuran contents.

Background: Dysmenorrhea is a major individual and public health problem in women. Recently, according to the high prevalence of dysmenorrhea, different medical treatments including herbal medicines have been used. Objective: The aim of this study is to evaluate the effect of ginger on dysmenorrhea severity in students in Qazvin University of Medical Science, Iran. Methods: In this randomized clinical trial, 100 female students aged 18 to 25 years with moderate to severe dysmenorrhea were included. The participants were allocated to two groups of control and intervention by randomization. The intervention group were received 500 mg of ginger tablet and 250 mg of Mefenamic Acid capsule twice a day and the control group took placebo and Mefenamic Acid 250 mg capsule two times a day from two days before and within the first three days of the onset of the Menstrual period. Pain intensity were measured with VAS tool before and two months after the prescription of drugs. Results: The results of our study showed the pain intensity after the intervention in the first month, was significantly less than the control group (3. 72 vs 5. 44) (P<0. 001) and in the second month, the pain in intervention group was significantly less than the control group (3. 2 vs5. 2) (P<0. 001), and no complications were observed in the intervention group. Conclusion: The result of this study indicated that herbal medicine like ginger has a great effect on reduction of dysmenorrhea severity and furthermore studies are suggested to perform in order to find a suitable dose of ginger for complete treatment of dysmenorrhea and other menstrual symptoms.

Background: In Persian medicine (PM), Achillea millefolium L. has a wide range of applications in the treatment of several diseases. Objective: The aim of this study is to introduce the viewpoints of PM scholars about this herb in the field of female diseases and to compare them with the recent studies. Methods: In this review study, therapeutic applications of Achillea millefolium in the field of female diseases were collected from credible Persian medical sources from 4th to 14th lunar centuries then current scientific databases such as PubMed and Google scholar were searched by using key world Achillea millefolium for collecting the findings of clinical, experimental and in vitro studies about this herb in the field of obstetrics and gynecology to compared to the PM scholars' viewpoints. Results: In PM, Achillea millefolium is recommended for treatment various female reproductive diseases such as menstrual disorders, facilitating labor, reducing adhesions of cervix, controlling uterine infections. In recent studies, therapeutic effects of this herb on ovarian cyst, menstrual cycle regulation and dysmenorrhea have been reported. Also, in several studies, the antibacterial and antifungal effects of this plant on controlling infections have been investigated; as well the extract of this plant has been effective in inhibiting the proliferation of ovarian adenocarcinoma cells. Conclusion: Considering the extensive uses of Achillea millefolium reflected in PM and recent studies, it seems that this plant can be used in many fields of female diseases to provide ideas for research and therapy.

Background: Safflower (Carthamus tinctorius L. ), is an important medicinal plant of Asteraceae family, which is a rich source of pharmaceutically active compounds including phenols, flavonoids and fatty acids. In traditional medicine this plant has been used as an herbal medicine to treat various diseases. Objective: The aim of this study was to evaluate the role of jasmonic acid to protect safflower against drought damages. Method: The greenhouse experiment was conducted as a factorial experiment in a completely randomized design with three replications. The first factor was irrigation regime, which was applied at four levels: field capacity (FC), 0. 8 FC, 0. 6 FC and 0. 4 FC. The second factor was application of jasmonic acid in three concentrations (0, 0. 5 and 1 mM). Results: According to the obtained results activities of antioxidant enzymes including catalase, superoxide dismutase and glutathione peroxidase, and also the amount of compounds like abscisic acid, proline, malondealdehyde, protein, phenols and flavonoids contents were significantly increased in safflower by enhancement of water stress. Conversely, relative leaf water content (RWC) exhibited a significant decrease due to water deficit. According to the obtained results, application of jasmonic acid can mitigate the adverse effect of drought stress on the mentioned attributes. Also, the amount of main fatty acids in the oil were significantly changed due to water deficient. Conclusion: The results illustrated that jasmonic acid has an important role in increasing safflower ability to cope against drought stress through improvement of antioxidant enzymes activities and enhancement of secondary methabolites.

Background: Ulcerative colitis is an idiopathic chronic, relapsing inflammation of the colon which is resulted from dysregulation of the mucosal immune system. In Iranian traditional medicine, oleoresin from Pistacia atlantica is used to treat gastrointestinal disorders, including peptic ulcers, dyspepsia and intestinal inflammation. Objective: In this study, we examined the therapeutic and protective effects of oleoresin in acetic acid-induced colitis in rat. Methods: The oleoresin was dissolved in Tween 80% (1% v / v) and doses of 100, 200 and 400 mg/kg were administered orally to animals. Three days after colitis induction, the rats were treated for 6 days and after determining the most effective dose in the treatment, the protective effect was evaluated using the optimal dose of the oleoresin for 6 days. In day 6, colitis was induced and continued for 3 days. At the end, animals were sacrificed for microscopic and macroscopic examination of colon tissues. Results: Dose dependently, Oleoresin of P. atlantica showed therapeutic effects on microscopic and macroscopic examination of colon tissue of rats with ulcerative colitis induced by acetic acid, in comparison with control group(P<0. 05). However, there was no significant difference between treatment groups and the control in the protective method (P>0. 05). Conclusion: This study showed the beneficial effects of anti-inflammatory and wound healing oleoresin of P. atlantica in acetic acid-induced ulcerative colitis in rats.

Background: Ketamine (KET) causes oxidative stress and liver damage. Hesperetin plays an important role in the prevention of inflammatory processes and associated with oxidative stress. Objective: The purpose of this study was to analyze the protective role of hesperetin and its nanocrystal on hepatotoxicity induced by ketamine in mice. Methods: In this research, 30 male mice were divided into six groups: control, poisoned (KET 10 mg/kg/10 day injected intraparitary), hesperetin and hesperetin nanoparticles treated poisoning groups (10 and 20 mg/kg for four weeks orally after KET administration). Finally, the malondialdehyde (MDA) and glutathione (GSH) levels, Catalase (CAT), Superoxide dismutase (SOD), Glutathione peroxidase (GPX) and Glutathione reductase (GRX) activity in liver tissue as well as the its histological changes were investigated. Results: The level of GSH and antioxidant enzyme activity in the liver were significantly (P <0. 05) decreased in the ketamin indused rat, and hesperetin and its nano significantly were increased (P <0. 01) GSH level and antioxidant enzyme activity. In contrast, MDA level in the liver was significantly (P <0. 01) increased in the the ketamin poioned rat, and nano hesperetin suppressed the ketamin-induced lipid proxidation. Ketamine also decreased number of hepatocytes (P<0. 001) and diameter of sinusoids (P <0. 05) in toxic mice. Whereas, Nano hesperetin increased antioxidant enzymes activities, diameter and nucleus diameter of hepatocytes and decreased MDA level (P <0. 05). Conclusion: The results of this study indicated that hesperetin and especially nano hesperetin due to antioxidant effects cause hepatoprotective against KET-induced oxidative stress.

Background: Fenugreek is a valuable medicinal plant and it is essential to investigate induction of mutations in order to increase its active ingredient. Objectives: In this study, the phytochemical and growth traits in hairy and normal roots of Fenugreek in response to gamma irradiation were evaluated. Method: In this study, gamma irradiation was applied to Iranian Fenugreek seeds in five doses (0, 100, 200, 300 and 400 Gy), and then the irradiation effects in root hair culture conditions in a completely randomized design (CRD) with three replications were evaluated. In order to induce hairy roots in fenugreek, ATCC15834 strain of Agrobacterium rhizogenesis was used. Results: The results showed that the different irradiation doses had a significant effect on all traits in normal and hairy roots. The comparison of mean of data showed that the highest values of traits were related to 100 Gy and the lowest values of traits related to irradiation of seeds with 400 Gy doses. The trigonelline content was significantly higher in hairy roots than normal roots, so that the amount of trigonelline of hairy roots at different treatments including 0, 100, 200, 300 and 400 Gy were 2. 46, 2. 67, 2. 66, 2. 44 and 2. 64 times more than normal roots, respectively. Conclusion: The results indicated that the cell proliferation, growth and amount of trigonelline were increased due to the stimulating effect of low doses of gamma irradiations.

Background: About 75% of women experience at least one vulvovaginal candidiasis during their life. Clotrimazole is an antifungal drug that has side effects along with its therapeutic properties. For this reason, a large percentage of women tend to use natural herbal treatments. Artemisia is an anti-fungal activity. Objective: The aim of this study was to compare the effect of Artemisia vulgaris and Clotrimazole on vaginal candida infection on non pregnant women in fertility ages. Methods: This study is a triple blind clinical trial performed on 72 non-pregnant women in Mashhad in 2016-2017 years. The research units were divided into two groups (receiving Artemisia Vaginal Cream and receiving Clotrimazole Vaginal Cream). After confirmation of candidacy and having consent for participation, by random allocation and treated for seven nights. After the treatment, the data was analyzed using SPSS software (version 24). Results: After treatment, the score for candidate vaginal symptoms was not significant in Artemisia and Clotrimazole group based on Mann-Whitney test (P = 0. 518). The Wilcoxon test showed a significant reduction in the symptoms of vaginal candida infection before and after treatment in both groups of Artemisia (P <0. 001) and clotrimazole (P <0. 001). Conclusion: Due to the similar effects of Artemisia and Cholitrimazole, Artemisia can be used as an alternative treatment for vaginal candidiasis due to less side effects.

Background: Despite the traditional use of the Adiantum capillus-veneris plant, there is little evidence of its clinical effects. Objective: The purpose of the present study was to investigate the effect of the Adiantum capillus-veneris extract on Immunohistochemical expression of Lung heat-Shock Proteins in rats exposed to hypoxia. Methods: Twenty-four male Wistar rats (control: 8, training-hypoxia: 8, training-hypoxiasupplement: 8) without clinically evident disease were used. The rats were exposed to hypoxia environment for 3 week following 6 weeks interval training. Tweleve of the experimental samples were taken 500 ml Adiantum capillus-veneris extract per body weight (kg) in during exposure to hypoxia environment. Finally lung tissue was removed for immunohistochemistry tests of HSP70 and HSP90. To analyze of data, ANOVA test was used (α ≤ 0. 05). Results: Expression of HSP70 and HSP90 increased significantly in hypoxia group comparison with the control group (P≤ 0. 05). Expression of HSP70 and HSP90 protein decreased significantly in the Supplement hypoxia group comparison with the hypoxia group (P≤ 0. 05). Conclusion: Reduction effects of Adiantum capillus-veneris extract on expression of the parenchyma lung heat-shock protein in hypoxia conditions was observed that probably indicate decreased oxidative stress in the lung.

Background: Pistacia atlantica subsp. kurdica is an endemic plant of Iran which belongs to Anacardiaceae family. This plant has been proposed as an efficacious remedy for gastrointestinal diseases such as inflammatory bowel disease, colitis, and peptic ulcer. Objective: In this study we decided to evaluate the efficacy and pharmacological mechanisms involved in anti-colitis effect of essential oil of Pistacia atlantica in Wistar rats. Method: Sixty Wistar rats were selected for this study and were categorized to 6 groups. Experimental colitis was induced with 3% acetic acid solution. Animals of treatment groups received different daily doses of the essential oil (25, 50, and 100 mg/Kg, orally) and. Sulphasalazine (as the standard drug), for 7 days. At the end of the study, the rats were sacrificed and the colon was removed and assessed for macroscopic and microscopic changes. Also, in order to identify the mechanisms involved in anti-colitis effect of this natural drug, the level of cyclooxygenase (COX)-2 were evaluated. Results: The essential oil of Pistacia atlantica gum significantly reduced macroscopic and microscopic scores of colitis compared with control group (P <0. 01). The essential oil with the dose of 100 mg/kg showed the highest anti-colitis effect. The oil of P. atlantica remarkably suppressed the level of COX-2 in colon tissue (P <0. 05). Conclusion: This research has proved the protective effect of oral administration of essential oil of P. atlantica gum on ulcerative colitis in rats. This natural drug performs anti-colitis potential through inhibiting the pro-inflammatory cytokines.

Background: Hypertension is a prevalent health problem worldwide. Complementary medicine is commonly used in the treatment of hypertension and Aromatherapy is one of the complementary therapies. Objective: The present study was conducted to investigate effects of aromatherapy using essential oils of damask rose on hypertension. Method: This clinical trial was conducted on 62 hypertension patients, who were randomly assigned to two intervention and control groups. In the intervention group, patients were treated with aromatherapy twice a day for two weeks, each lasting 2 minutes, by inhaling three drops of essential oils of damask rose instill on a piece of cotton. In the control group, placebo was used. Blood pressure of the patients was measured on days 2, 5, 9, 14, and 16. The obtained data were analyzed using statistical independent t-test and repeated measure analysis of variance at P < 0. 05. Results: Both groups were homogenous in terms of demographic specifications. The results showed a statistically significant decrease in systolic blood pressure between the intervention and control groups. Aromatherapy in the intervention group resulted in a statistically significant decrease in diastolic blood pressure, only on day 12. Moreover, on the fifth to the twelfth days, the effect of aromatherapy on pulse decrease in intervention group was more evident than the control group. Conclusion: Based on the obtained results, essential oils of damask rose can be used as an effective supplementary treatment of hypertension.

Background: Obesity and overweight are widely expending in worldwide and containing a wide range of diseases, such as glucose homeostasis disorders. Green coffee and exercise are as suitable treatment options for this condition. Objective: The aim was to evaluate the simultaneous effects of green coffee consumption and combine training on body composition and glucose homeostasis in overweight and obese women. Method: 26 overweight and obese women were randomly divided into three green coffee (n=9), combined training (n=10) and green coffee-combined training (n=7) groups. Green coffee powder was consumed daily as two 125 mg per day before lunch and dinner. Combine training was contain of six weeks, four session per week of progressive endurance-strength training. Insulin, fast blood suger and HOMA and body composition factors were measured before and after the end of interventions. Results: Weight, body mass index (BMI), waist circumference, hip circumference, waist to hip ratio (WHR), fat percent, insulin and HOMA levels were significantly decrease in all three groups that the reduction for all variables except waist circumference, WHR, insulin and HOMA were higher in green coffee-combine training group than two other groups (P<0. 05). Blood glucose changes was not significant in any groups (P>0. 05). Conclusion: Results indicated that maybe both green coffee and combine training are effective for improve body composition, insulin and HOMA levels and simultaneous usage of green coffee combine with combine training have synergistic effects on improving body composition.

Background: Atropine and scopolamine are important alkaloids that are widely used in the pharmaceutical industry. Objective: Determination of the effects of PGPR (Plant growth-promoting rhizobacteria) on phytochemical and morpho-physiological traits of Atropa belladonna L. under greenhouse conditions. Method: This study was done as a factorial experiment based on a randomized complete block design with 3 replications. PGPR in four levels including control or no inoculation, Pseudomonas, Azotobacter, Pseudomonas + Azotobacter and Thiobacillus + Sulfur as the first factor, and also chemical fertilizer at three levels including no fertilizer, 50% recommended fertilizer and 100% recommended fertilizer as second factor were used. Results: The PGPR and chemical fertilizer and their interactions had significant effect (P ≤ 0. 01) on phytochemical and morpho-physiological traits. The highest values of root volume, root diameter and root dry weight were obtained from treatment of Azotobacter with 50% recommended fertilizer. The highest atropine and scopolamine levels of leaf (19. 58 and 7. 77 mg/g, respectively) were observed in no bacteria inoculation with 50% chemical fertilizer. The highest root atropine content was 7. 69 mg/g which related to treatment of Thiobacillus + sulfur with 100% recommended fertilizer. The highest content of root scopolamine (5. 69 mg/g) was observed in treatment of no bacteria inoculation with 50% recommended fertilizer. Conclusion: Generally, the results showed that PGPRs (plant growth-promoting rhizobacteria) improved the quantitative and qualitative performance of A. belladonna.

Background: Ischemic heart disease is the main cause of mortality worldwide. Objective: The aim of this study was to investigate the effect of intragastric administration of pomegranate fleshy mesocarp (membrane) extract on isolated rat heart following myocardial ischemia and reperfusion. Methods: Wistar rat’ s hearts were removed under deep anesthesia and were studied using Langendorff’ s apparatus. During the first stage of the study, isolated hearts in groups of 3 received different concentrations (0. 5-0. 00001%) of the extract dissolved in Krebs solution. The control group received pure Krebs solution. During the second stage of the study, the control and the test rats, in groups of 10, received distilled water or the ethanol extract of pomegranate juice (200 mg/kg), respectively, daily for 3 weeks. At the end of the experimental period, the hearts of the animals were studied. After 30 min stabilization, all hearts experienced 30 min global ischemia followed by 120 min reperfusion. Results: Supplementation of pomegranate membrane extract to perfusion solution of isolated hearts suppressed cardiac mechanical activity and increased coronary perfusion pressure. Intragastric administration of the extract caused a significant increase in heart rate and ventricular contractile force. In addition, coronary perfusion pressure increased, and the infarct size significantly decreased compared to the control group. Conclusion: Direct administration of the extract to isolated hearts results in cardiac depression. However, intragastric administration of the extract causes strong cardioprotective effects against ischemia and reperfusion induced injury in isolated rat hearts.

Background: Oxidative stress results from imbalance in the body's redox position, which results in tissue damage due to increased intracellular radicals. Antioxidants prevent the oxidation of fatty acids and prevent foam cells and atherosclerotic plaque. Portulaca, which is one of the supplements, is considered as an antioxidant-rich plant. Objective: The purpose of this study was to evaluate the effect of eight weeks of Portulaca supplementation on antioxidant enzymes and oxidative stress in non-active girls. Methods: This quasi-experimental study was conducted on non-active girls (overweight and obese) with an age range of 20-30 years in Azarbaijan Shahid Madani University. 20 subjects were qualified and randomly divided into two control (n = 10) and complement (n = 10) groups. Subjects of supplemented group received 1200 portulaca mg per day for eight weeks. Data were analyzed by t-test using by SPSS20 software. Statistical significance criterion was set as P<0. 05. Results: The results showed that serum levels of superoxide dismutase (SOD), glutathione peroxidase(GPX) and total antioxidant capacity (TAC) were significantly increased in the supplemented group (P<0. 05), while the amount of malondialdehyde (MAD) decreased, this decline was not statistically significant (P> 0. 05). Conclusion: Portulaca supplements are likely to be effective in improving cardiovascular health and preventing cardiovascular disease and strengthening the antioxidant system in overweight and obese people, and destroys lipid peroxidation that produces ROS.

Background: The aqueous extract of some plants has an antibacterial effect on pathogenic bacteria for humans. Objective: This study designed to investigate the antimicrobial activity of aqueous extract of some plants on some food-borne pathogenic bacteria in a laboratory setting has done. Method: In an experimental study, plants collected from of Tehran city and aqueous extract of them, extracted. To determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) with two ways of visual and turbidity (OD), serially different concentrations (1. 25-80 mg/ml) on different cultures was prepared. Disc diffusion (DD) test in concentrations of 10, 20 and 40 mg/ml to determine the average diameter of inhibition for some bactria, done. Results: The results showed that the inhibitory and fungicidal aqueous extract of Solanum americanum on various bacteria was more than any other aqueous extracts (Staphylococcus aureus MIC = 10 mg/ml) and also Staphylococcus aureus and Salmonella typhimurium were the most sensitive and most resistant bacteria to aqueous extract, respectively. Conclusion: According to the results, we can be hopeful the extract of Solanum americanum in the treatment of pathogenic bacteria such as S. aureus, can be help and it can used in the food industry as a food protection. Recommended by extracting the active ingredients of the extract of this plant and other plants, more research done on the composition of extract.