Biochemical and Histopathological Evidence on the Beneficial Effects of Essential Oil of Pistacia atlantica Oleoresin in Acetic Acid-induced Colitis

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BAHRAMI GH.R.; Sotoudehkia sh.; HOSSEINZADEH L.; FARZAEI M.H.; SHOKOOHINIA Y.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Medicinal Plants Year:2019 | Volume:18 | Issue:72 Page(s): 192-201

Download Full-Text

Persian Verion

View:

574

Download:

Cites:

Information Journal Paper

Title

Biochemical and Histopathological Evidence on the Beneficial Effects of Essential Oil of Pistacia atlantica Oleoresin in Acetic Acid-induced Colitis

Author(s)

Keywords

Pistacia atlanticaQ1

Herbal medicineQ1

Inflammatory bowel diseaseQ1

Inflammatory cytokinesQ1

Abstract

Background: Pistacia atlantica subsp. kurdica is an endemic plant of Iran which belongs to Anacardiaceae family. This plant has been proposed as an efficacious remedy for gastrointestinal diseases such as Inflammatory bowel disease, colitis, and peptic ulcer. Objective: In this study we decided to evaluate the efficacy and pharmacological mechanisms involved in anti-colitis effect of essential oil of Pistacia atlantica in Wistar rats. Method: Sixty Wistar rats were selected for this study and were categorized to 6 groups. Experimental colitis was induced with 3% acetic acid solution. Animals of treatment groups received different daily doses of the essential oil (25, 50, and 100 mg/Kg, orally) and. Sulphasalazine (as the standard drug), for 7 days. At the end of the study, the rats were sacrificed and the colon was removed and assessed for macroscopic and microscopic changes. Also, in order to identify the mechanisms involved in anti-colitis effect of this natural drug, the level of cyclooxygenase (COX)-2 were evaluated. Results: The essential oil of Pistacia atlantica gum significantly reduced macroscopic and microscopic scores of colitis compared with control group (P <0. 01). The essential oil with the dose of 100 mg/kg showed the highest anti-colitis effect. The oil of P. atlantica remarkably suppressed the level of COX-2 in colon tissue (P <0. 05). Conclusion: This research has proved the protective effect of oral administration of essential oil of P. atlantica gum on ulcerative colitis in rats. This natural drug performs anti-colitis potential through inhibiting the pro-Inflammatory cytokines.

Cites

No record.

References

Cite

APA: Copy

BAHRAMI, GH.R., Sotoudehkia, sh., HOSSEINZADEH, L., FARZAEI, M.H., & SHOKOOHINIA, Y.. (2019). Biochemical and Histopathological Evidence on the Beneficial Effects of Essential Oil of Pistacia atlantica Oleoresin in Acetic Acid-induced Colitis. JOURNAL OF MEDICINAL PLANTS, 18(72 ), 192-201. SID. https://sid.ir/paper/15378/en

Vancouver: Copy

BAHRAMI GH.R., Sotoudehkia sh., HOSSEINZADEH L., FARZAEI M.H., SHOKOOHINIA Y.. Biochemical and Histopathological Evidence on the Beneficial Effects of Essential Oil of Pistacia atlantica Oleoresin in Acetic Acid-induced Colitis. JOURNAL OF MEDICINAL PLANTS[Internet]. 2019;18(72 ):192-201. Available from: https://sid.ir/paper/15378/en

IEEE: Copy

GH.R. BAHRAMI, sh. Sotoudehkia, L. HOSSEINZADEH, M.H. FARZAEI, and Y. SHOKOOHINIA, “Biochemical and Histopathological Evidence on the Beneficial Effects of Essential Oil of Pistacia atlantica Oleoresin in Acetic Acid-induced Colitis,” JOURNAL OF MEDICINAL PLANTS, vol. 18, no. 72 , pp. 192–201, 2019, [Online]. Available: https://sid.ir/paper/15378/en

Related Journal Papers