ANTINOCICEPTIVE EFFECTS OF ESSENTIAL OIL OF SALVIA OFFICINALIS L. IN MICE

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EYDI AKRAM; EYDI MARYAM; BADIEI LEYLA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Journal of Medicinal Plants Year:2008 | Volume:7 | Issue:28 Page(s): 94-99

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Information Journal Paper

Title

ANTINOCICEPTIVE EFFECTS OF ESSENTIAL OIL OF SALVIA OFFICINALIS L. IN MICE

Author(s)

EYDI AKRAM | EYDI MARYAM | BADIEI LEYLA | Issue Writer Certificate

Keywords

SALVIA OFFICINALISQ2

PAINQ2

MICEQ3

FORMALIN TEST‍‍‍‍‍Q3

Abstract

Background: PAIN is a sensory modality, which in many cases represents the only symptom for the diagnosis of several diseases. It often has a protective function. Although morphine has reigned for centuries as the king of PAINkillers, its rule hasn’t been totally benign. There are concerns about its addictive properties and side effects, which include respiratory depression, drowsiness, decreased gastrointestinal motility, nausea and several alterations of the endocrine and autonomic nervous systems. Since SALVIA OFFICINALIS (sage) is used traditionally in the treatment of PAINful illnesses, it became worthwhile to evaluate its antinociceptive activities in MICE.Objective: The objective of the present work is to evaluate the analgesic activity of essential oil of sage leaves by the formalin test in MICE.Methods: The interaction between the plant leaves and opioidergic system on formalin-induced PAIN were carried out. The essential oil (0.2, 0.25 and 0.3 ml/kg) was injected intraperitoneally. The control groups were administered sunflower oil as vehicles of essential oil. Also, the LD50 of the essential oil of the plant was measured.Results: The results showed that the essential oil of the plant (0.3 ml/kg) decreased both phases of PAIN. Also, the antinociceptive effect of essential oil (0.3 ml/kg) and morphine (0.5 ml/kg body wt.) were reversed by pretreatment with naloxone (0.5 ml/kg). The LD50 of the essential oil was found 0.5 ml/kg, i.p.Conclusion: The potent analgesic effects were blocked by naloxone, indicating that the analgesic effects are associated with the activation of opioid receptors in the central nervous system. The present data indicate that the plant has analgesic effects on MICE and the plant should be considered in future therapeutic researches.

Cites

EFFECT OF SALVIA OFFICINALIS L. ON SERUM LEVEL OF GLUCOSE, LIPID PROFILES AND TISSUE LEVEL OF MALONDIALDEHYDE IN DIABETIC RATS

References

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APA: Copy

EYDI, AKRAM, EYDI, MARYAM, & BADIEI, LEYLA. (2008). ANTINOCICEPTIVE EFFECTS OF ESSENTIAL OIL OF SALVIA OFFICINALIS L. IN MICE. JOURNAL OF MEDICINAL PLANTS, 7(28), 94-99. SID. https://sid.ir/paper/15420/en

Vancouver: Copy

EYDI AKRAM, EYDI MARYAM, BADIEI LEYLA. ANTINOCICEPTIVE EFFECTS OF ESSENTIAL OIL OF SALVIA OFFICINALIS L. IN MICE. JOURNAL OF MEDICINAL PLANTS[Internet]. 2008;7(28):94-99. Available from: https://sid.ir/paper/15420/en

IEEE: Copy

AKRAM EYDI, MARYAM EYDI, and LEYLA BADIEI, “ANTINOCICEPTIVE EFFECTS OF ESSENTIAL OIL OF SALVIA OFFICINALIS L. IN MICE,” JOURNAL OF MEDICINAL PLANTS, vol. 7, no. 28, pp. 94–99, 2008, [Online]. Available: https://sid.ir/paper/15420/en

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