EFFECT OF POLAR AND NOM-POLAR ALOE VERA L. LEAF EXTRACTS ON α-AMYLASE AND Α-GLUCOSIDASES INHIBITORY ACTIVITY IN VITRO

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FALLAH HUSEINI H.; ASGHARI B.; ASGARPANAH J.; BABAEI ZARCH A.; EGHBALI ZARCH T.

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Journal Paper

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Journal: Journal of Medicinal Plants Year:2013 | Volume:12 | Issue:48 Page(s): 160-169

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Title

EFFECT OF POLAR AND NOM-POLAR ALOE VERA L. LEAF EXTRACTS ON α-AMYLASE AND Α-GLUCOSIDASES INHIBITORY ACTIVITY IN VITRO

Author(s)

Keywords

ALOE VERA L.Q2

DIABETESQ2

ENZYME INHIBITIONQ2

α-GLUCOSIDASEQ3

α-AMYLASEQ2

Abstract

Background: Intestinal a-glucosidase and α-amylase are two carbohydrate-hydrolysing enzymes that play a key role in conversion of disaccharide to glucose. Inhibition of these two enzymes provides a therapeutic option for treatment of postprandial hyperglycemia in diabetic patients.Objective: The aim of the current study was to evaluate the inhibitory effects of different ALOE VERA L. extracts against α-amylase and a-glucosidase in vitro.Methods: ALOE VERA L. leaf was collected from the Institute of Medicinal Plants farm and several extracts were prepared by n-hexane, chloroform, ethyl acetate and methanol solvents. The inhibitory effects of the extracts were tested on α-amylase and α-glucosidase enzyme separately. In this experiment, the minimum concentration of the extract required for 50% inhibition of enzyme activity (IC50), was obtained and compared with acarbose as a positive control.Results: The results showed that total methanol extract of ALOE VERA L. leaf had significantly (p<0.001) higher a-amylase inhibitory (28.2 ± 1.3 mg/ml) effect than other solvent fractions but lower than acarbose (25.4 ± 1.9 mg/ml). Furthermore total methanol extract and solvent fractions of methanol and ethyl acetate of ALOE VERA L. leaf had significantly (p<0.001) higher inhibitory effect on a-glucosidase enzyme activity (2.3 ± 0.1 mg/ml, 2.7 ± 0.1 mg/ml, 3.4 ± 0.1 mg/ml, respectively) than other solvent fractions as well as compared with acarbose (5.8 ± 0.6 mg/ml).Conclusion: Total methanol extracts of ALOE VERA L. leaf has strong α-amylase and a-glucosidase inhibitory activity than chloroform, n-hexane, chloroform, ethyl acetate and methanol solvent fraction.

Cites

Persian Thyme (Thymus persicus): A Plant Containing Active Metabolites with Antioxidant, Anti-diabetic and Anti-Alzheimer Effects

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APA: Copy

FALLAH HUSEINI, H., ASGHARI, B., ASGARPANAH, J., BABAEI ZARCH, A., & EGHBALI ZARCH, T.. (2013). EFFECT OF POLAR AND NOM-POLAR ALOE VERA L. LEAF EXTRACTS ON α-AMYLASE AND ?-GLUCOSIDASES INHIBITORY ACTIVITY IN VITRO. JOURNAL OF MEDICINAL PLANTS, 12(48), 160-169. SID. https://sid.ir/paper/15452/en

Vancouver: Copy

FALLAH HUSEINI H., ASGHARI B., ASGARPANAH J., BABAEI ZARCH A., EGHBALI ZARCH T.. EFFECT OF POLAR AND NOM-POLAR ALOE VERA L. LEAF EXTRACTS ON α-AMYLASE AND ?-GLUCOSIDASES INHIBITORY ACTIVITY IN VITRO. JOURNAL OF MEDICINAL PLANTS[Internet]. 2013;12(48):160-169. Available from: https://sid.ir/paper/15452/en

IEEE: Copy

H. FALLAH HUSEINI, B. ASGHARI, J. ASGARPANAH, A. BABAEI ZARCH, and T. EGHBALI ZARCH, “EFFECT OF POLAR AND NOM-POLAR ALOE VERA L. LEAF EXTRACTS ON α-AMYLASE AND ?-GLUCOSIDASES INHIBITORY ACTIVITY IN VITRO,” JOURNAL OF MEDICINAL PLANTS, vol. 12, no. 48, pp. 160–169, 2013, [Online]. Available: https://sid.ir/paper/15452/en

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