STUDY OF ANTICONVULSANT ACTIVITY OF VALERIANA OFFICINALIS ROOTS AND RHIZOMES HYDROALCOHOLIC EXTRACT IN MICE AND RELATION TO NITRIC OXIDE

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KARIMI GH.; HOSSEINZADEH H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Medicinal Plants Year:2003 | Volume:2 | Issue:7 Page(s): 43-48

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Title

STUDY OF ANTICONVULSANT ACTIVITY OF VALERIANA OFFICINALIS ROOTS AND RHIZOMES HYDROALCOHOLIC EXTRACT IN MICE AND RELATION TO NITRIC OXIDE

Author(s)

KARIMI GH. | HOSSEINZADEH H. | Issue Writer Certificate

Keywords

VALERIANA OFFICINALISQ3

PTZQ3

MESQ4

NITRIC OXIDEQ3

Abstract

The anticonvulsant effect of VALERIANA OFFICINALIS roots and rhizomes hydroalcoholic extract was studied, utilizing maximal electroshock (MES) and pentylenetetrazole (PTZ) tests. In the PTZ test, the extract (0.3-3 g/kg,ip) increased the onset time of Tonic Hind Limb Extension dose - dependently. In the MES test, neither of doses showed antiseizure activity. L - NAME (1-10 mg/kg ip) reduced the anticonvulsant effect of extract in the PTZ test. The results suggest that VALERIANA OFFICINALIS extract could be a candidate for treatment of petitmal seizure and NITRIC OXIDE may be involved in this effect.

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References

EDRF RELEASE ON ACTIVATION OF NMDA RECEPTORS SUGGESTS ROLE AS INTRACELLULAR MESSENGER IN THE BRAIN

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APA: Copy

KARIMI, GH., HOSSEINZADEH, H.,. (2003). STUDY OF ANTICONVULSANT ACTIVITY OF VALERIANA OFFICINALIS ROOTS AND RHIZOMES HYDROALCOHOLIC EXTRACT IN MICE AND RELATION TO NITRIC OXIDE. JOURNAL OF MEDICINAL PLANTS, 2(7), 43-48. SID. https://sid.ir/paper/15569/en

Vancouver: Copy

KARIMI GH., HOSSEINZADEH H.. STUDY OF ANTICONVULSANT ACTIVITY OF VALERIANA OFFICINALIS ROOTS AND RHIZOMES HYDROALCOHOLIC EXTRACT IN MICE AND RELATION TO NITRIC OXIDE. JOURNAL OF MEDICINAL PLANTS[Internet]. 2003;2(7):43-48. Available from: https://sid.ir/paper/15569/en

IEEE: Copy

GH. KARIMI, H. HOSSEINZADEH, an, “STUDY OF ANTICONVULSANT ACTIVITY OF VALERIANA OFFICINALIS ROOTS AND RHIZOMES HYDROALCOHOLIC EXTRACT IN MICE AND RELATION TO NITRIC OXIDE,” JOURNAL OF MEDICINAL PLANTS, vol. 2, no. 7, pp. 43–48, 2003, [Online]. Available: https://sid.ir/paper/15569/en

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