Protective Effect of Lantana camara Methanolic Leaf Extract Against Acetaminophen-induced Liver Injury in Male Albino Rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Stephen Hyelda; Bello Balaraba

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: PHARMACEUTICAL AND BIOMEDICAL RESEARCH Year:2024 | Volume:10 | Issue:2 Page(s): 135-146

Download Full-Text

View:

Download:

Cites:

Information Journal Paper

Title

Protective Effect of Lantana camara Methanolic Leaf Extract Against Acetaminophen-induced Liver Injury in Male Albino Rats

Author(s)

Stephen Hyelda | Bello Balaraba | Issue Writer Certificate

Keywords

Lantana camara

Acetaminophen

Antioxidants

Phytochemicals

Acute liver injury

Abstract

Background: Lantana camara is used traditionally against liver ailments, but scientific evidence for its hepatoprotective effects is limited. Objectives: This study evaluates the hepatoprotective effect of methanolic leaf extract of L. camara against acetaminophen-(APAP) induced hepatotoxicity in a rat model. Methods: Phytochemical analysis revealed the presence of phenolics (5. 03%), alkaloids (4. 30%), saponins (6. 14%), tannins (3. 81%) and flavonoids (3. 54%) in the extract. Methanolic leaf extract of L. camara was administered orally to rats at 100, 300 and 500 mg/kg doses for 5 days before APAP challenge at 750 mg/kg. Serum liver enzymes, proteins, bilirubin and histopathology were assessed to determine the extent of liver injury and protection. Results: APAP administration caused significant (P<0. 05) elevation of serum aspartate transaminase (AST) (89. 57±6. 90 U/L), alanine transaminase (ALT) (35. 61±0. 81 U/L), alkaline phosphatase (ALP) (124. 90±1. 94 U/L), and bilirubin levels along with a reduction of total protein (57. 77±0. 73 g/L) and albumin levels (25. 21±1. 08 g/L). It also induced severe hepatocellular necrosis and inflammation. Pretreatment with 300 mg/kg extract dose conferred optimal protection by normalizing enzyme activities (AST: 58. 61±2. 88 U/L, ALT: 23. 57±1. 71 U/L, ALP: 92. 99±9. 87 U/L) and liver function biomarkers (total protein: 80. 42±1. 72 g/L, albumin: 27. 79±1. 91 g/L). It also preserved near-normal liver tissue architecture with minimal necrosis, indicating its antioxidant and membrane-stabilizing properties. Conclusion: The findings validate the ethnomedicinal use of L. camara and indicate its potential for development as an affordable therapy for APAP overdose liver damage.

Multimedia

No record.

Cites

No record.

References