ANTIDIABETIC EFFECTS OF JUGLANS REGIA LEAVE’S METHANOLIC EXTRACT ON ALLOXAN-INDUCED MALE WISRAR RATS

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TEYMOURI SHABAN M.; MONTASER KOUHSARI SH.; GHAFARZADEGAN R.; HAJI AGHAEI R.

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Journal: Journal of Medicinal Plants Year:2010 | Volume:9 | Issue:34 Page(s): 142-149

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Title

ANTIDIABETIC EFFECTS OF JUGLANS REGIA LEAVE’S METHANOLIC EXTRACT ON ALLOXAN-INDUCED MALE WISRAR RATS

Author(s)

TEYMOURI SHABAN M. | MONTASER KOUHSARI SH. | GHAFARZADEGAN R. | HAJI AGHAEI R. | Issue Writer Certificate

Keywords

JUGLANS REGIAQ3

BLOOD GLUCOSEQ3

TOTAL CHOLESTEROLQ3

ANTIOXIDANTQ2

Abstract

Background: JUGLANS REGIA leaves have ANTIOXIDANT effects and have been used in Iranian traditional medicines for its hypoglycaemic properties in the treatment of diabetes.Objective: This study is designed to evaluate the antidiabetic effects of JUGLANS REGIA leave’s methanolic extract (JRLME).Methods: Alloxan-induced diabetic male wistar rats have treated with JRLME at doses of 250 mg/kg and 500 mg/kg for three weeks and its effects investigated on various biochemical parameters such as postprandial BLOOD GLUCOSE level (short term and long term treatment by JRLME), oral glucose tolerance, TOTAL CHOLESTEROL (TC), Triglyceride (TG), LDL-cholesterol, HDL-cholesterol and VLDL levels, enzymatic activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) using commercial kits. Results: The obtained results showed a decrease (31%) in the BLOOD GLUCOSE level within 3 to 8 hours and also a significant decrease (44%) at the end of three weeks of feeding JRLME. The JRLME also decreased markedly TG (14%) and TC (7.6%) levels in blood serum. In addition, ANTIOXIDANT effect of JRLME was determined from elevated GPX, SOD and CAT activities by 22, 12 and 9%, respectively, as compared to diabetic control group (DC). However, the data about CAT activity was not significant as compared to diabetic control group (DC).Conclusion: We concluded that JUGLANS REGIA leaves have multifunctional ameliorating effects in diabetic metabolic conditions.

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APA: Copy

TEYMOURI SHABAN, M., MONTASER KOUHSARI, SH., GHAFARZADEGAN, R., & HAJI AGHAEI, R.. (2010). ANTIDIABETIC EFFECTS OF JUGLANS REGIA LEAVE’S METHANOLIC EXTRACT ON ALLOXAN-INDUCED MALE WISRAR RATS. JOURNAL OF MEDICINAL PLANTS, 9(34), 142-149. SID. https://sid.ir/paper/15717/en

Vancouver: Copy

TEYMOURI SHABAN M., MONTASER KOUHSARI SH., GHAFARZADEGAN R., HAJI AGHAEI R.. ANTIDIABETIC EFFECTS OF JUGLANS REGIA LEAVE’S METHANOLIC EXTRACT ON ALLOXAN-INDUCED MALE WISRAR RATS. JOURNAL OF MEDICINAL PLANTS[Internet]. 2010;9(34):142-149. Available from: https://sid.ir/paper/15717/en

IEEE: Copy

M. TEYMOURI SHABAN, SH. MONTASER KOUHSARI, R. GHAFARZADEGAN, and R. HAJI AGHAEI, “ANTIDIABETIC EFFECTS OF JUGLANS REGIA LEAVE’S METHANOLIC EXTRACT ON ALLOXAN-INDUCED MALE WISRAR RATS,” JOURNAL OF MEDICINAL PLANTS, vol. 9, no. 34, pp. 142–149, 2010, [Online]. Available: https://sid.ir/paper/15717/en

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