NEUROPROTECTIVE EFFECT OF MENTHA LONGIFOLIA L. EXTRACT ON ISCHEMIA/REPERFUSION-INDUCED BRAIN INJURY IN MALE WISTAR RATS

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FATHI F.; ORYAN SH.; RAFIEIAN M.; EIDI A.

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Journal: Journal of Medicinal Plants Year:2015 | Volume:14 | Issue:54 Page(s): 169-182

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Title

NEUROPROTECTIVE EFFECT OF MENTHA LONGIFOLIA L. EXTRACT ON ISCHEMIA/REPERFUSION-INDUCED BRAIN INJURY IN MALE WISTAR RATS

Author(s)

FATHI F. | ORYAN SH. | RAFIEIAN M. | EIDI A. | Issue Writer Certificate

Keywords

ANTIOXIDANT ACTIVITYQ2

CEREBRAL ISCHEMIAQ3

LIPID PEROXIDATIONQ2

MENTHA LONGIFOLIA L. EXTRACTQ2

REPERFUSIONQ2

Abstract

Background: Recent studies have suggested that Mentha long ifolia L. extracts (ME) have antioxidant activities.Objective: In this paper, attempts were made to determine the effect of Mein rat stroke model.Methods: Five groups (n=14) were studied; the first and second groups (control and sham) received intraperitoneal injection with daily distilled water. The other three groups received 50, 100 and 200 mg/kg/day of the ME for 21 days. Two hours after the last dose, each main group was subdivided into middle cerebral artery occlusion (MCAO) operated for infarct volume assessment and intact subgroup for the assessment of brain and serum ANTIOXIDANT ACTIVITY and lipid proxidation of brain and serum, respectively.Results: Pretreatment with ME resulted in a significant reduction in total infarct volume. ME significantly increased ANTIOXIDANT ACTIVITY in penumbra and core in comparation with the control. The ANTIOXIDANT ACTIVITY of serum in the 100 mg/kg/day group was significantly higher than that of the control group. Malondialdeyde (MDA) level in the penumbra area was significantly elevated in the control group in comparison with other pretreated groups. ME at dose of 100 mg/kg significantly decreased MDA level in core area scale to the control. Moreover, ME with the doses of 100 and 200 mg/kg/day reduced MDA level of serum.Conclusion: ME may protect ischemia/reperfusion induced brain injury by increase in ANTIOXIDANT ACTIVITY, decrease in lipid proxidation and reduction in infarction volume.

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APA: Copy

FATHI, F., ORYAN, SH., RAFIEIAN, M., & EIDI, A.. (2015). NEUROPROTECTIVE EFFECT OF MENTHA LONGIFOLIA L. EXTRACT ON ISCHEMIA/REPERFUSION-INDUCED BRAIN INJURY IN MALE WISTAR RATS. JOURNAL OF MEDICINAL PLANTS, 14(54), 169-182. SID. https://sid.ir/paper/15815/en

Vancouver: Copy

FATHI F., ORYAN SH., RAFIEIAN M., EIDI A.. NEUROPROTECTIVE EFFECT OF MENTHA LONGIFOLIA L. EXTRACT ON ISCHEMIA/REPERFUSION-INDUCED BRAIN INJURY IN MALE WISTAR RATS. JOURNAL OF MEDICINAL PLANTS[Internet]. 2015;14(54):169-182. Available from: https://sid.ir/paper/15815/en

IEEE: Copy

F. FATHI, SH. ORYAN, M. RAFIEIAN, and A. EIDI, “NEUROPROTECTIVE EFFECT OF MENTHA LONGIFOLIA L. EXTRACT ON ISCHEMIA/REPERFUSION-INDUCED BRAIN INJURY IN MALE WISTAR RATS,” JOURNAL OF MEDICINAL PLANTS, vol. 14, no. 54, pp. 169–182, 2015, [Online]. Available: https://sid.ir/paper/15815/en

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