The Military Utilization of Cognitive Biomarkers: Diagnostic and Therapeutic Methods,A Non-Systematic Review

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Alizadeh Mohammad; Zeinoddini Mehdi; Chitsaz Sadeghi Ahmad

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Journal Paper

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Journal: Journal of Police Medicine Year:2024 | Volume:13 | Issue:1 Page(s): 1-26

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Information Journal Paper

Title

The Military Utilization of Cognitive Biomarkers: Diagnostic and Therapeutic Methods,A Non-Systematic Review

Author(s)

Alizadeh Mohammad | Zeinoddini Mehdi | Chitsaz Sadeghi Ahmad | Issue Writer Certificate

Keywords

biomarker

brain function

cognitive disorders

military personnel

treatment

Abstract

Aims: Cognitive biomarkers are indicative of the diagnosis or progression of cognitive disorders. military personnel can suffer from numerous behavioral disorders that affect their cognitive processes. Therefore, the present study aimed to identify the most important effective biomarkers and investigate therapeutic opportunities based on them in order to improve the psychological disorders in question. Materials and Methods: In the present non-systematic review study, after identifying keywords equivalent to psychological disorders such as post-traumatic stress disorder, major depression, and chronic stress in MeSH among military personnel between 2000 and 2024, articles related to biomarkers involved in the target psychological disorders and their corresponding drug combinations were searched in Scopus, PubMed, Embase, ISI, and Google Scholar databases. Finally, the obtained data were collected and interpreted. Findings: The data indicated the presence of 56 cognitive biomarkers linked to the aforementioned disorders. These biomarkers encompass a range of indicators such as those associated with the hypothalamic-pituitary-adrenal (HPA) axis, steroid hormones, metabolic hormones, immune system, proteomics factors, inflammation factors, serotonin receptors, growth factors, autonomic nervous system, endocrine system, and antioxidants. These biomarkers are the focus of various clinical studies as potential functional biological targets for pharmaceutical compound development. Conclusion: Psychological disorders can have profound implications on the well-being of military personnel and their effectiveness in carrying out duties, impacting both their own health and that of others. Hence, precise screening and identification of diagnostic factors are crucial for implementing appropriate treatment measures, particularly among military personnel.

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